Relationship of granulocyte colony stimulating factor with other acute phase reactants in man

被引:18
作者
Noursadeghi, M [1 ]
Pepys, MB
Gallimore, R
Cohen, J
机构
[1] Hammersmith Hosp, Imperial Coll Sch Med, Dept Infect Dis & Microbiol, London W12 0NN, England
[2] UCL Royal Free & Univ Coll Med Sch, Dept Med, Ctr Amyloidosis & Acute Phase Prot, London, England
关键词
acute phase response; cardiothoracic surgery; G-CSF; human;
D O I
10.1111/j.1365-2249.2005.02732.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimulus and we show here that this procedure caused increased production of G-CSF, in addition to increases in the circulating concentrations of the proinflammatory cytokine interleukin (IL)-6 and the acute phase plasma proteins C-reactive protein (CRP) and serum amyloid A protein (SAA). Values of G-CSF correlated positively with IL-6 concentrations and circulating neutrophil counts, but not with CRP values. These results confirm that G-CSF is a physiological component of the acute phase response in humans that shares some of the same regulatory controls as IL-6, but its downstream effects are on neutrophils, not hepatic acute phase protein synthesis. Our observations are compatible with a protective role against bacterial infection for G-CSF in the human acute phase response, and support investigation of the prophylactic use of G-CSF in at-risk patients.
引用
收藏
页码:97 / 100
页数:4
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