NF-κB and MicroRNA Deregulation Mediated by HTLV-1 Tax and HBZ

被引：23

作者：

Fochi, Stefania ^{[1
]}

Ciminale, Vincenzo ^{[2
,3
]}

Trabetti, Elisabetta ^{[1
]}

Bertazzoni, Umberto ^{[1
]}

D'Agostino, Donna M. ^{[4
]}

Zipeto, Donato ^{[1
]}

Romanelli, Maria Grazia ^{[1
]}

机构：

[1] Univ Verona, Sect Biol & Genet, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy

[2] Univ Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy

[3] IRCCS, Veneto Inst Oncol IOV, I-35128 Padua, Italy

[4] Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy

来源：

PATHOGENS | 2019年 / 8卷 / 04期

关键词：

HTLV-1; Tax; NF-kappa B; HBZ; miRNA; T-CELL LEUKEMIA; VIRUS TYPE-I; ADHESION MOLECULE-1 GENE; LYMPHOTROPIC VIRUS; TYPE-1; TAX; TRANSCRIPTIONAL ACTIVATION; PERSISTENT ACTIVATION; KINASE COMPLEX; IKK-ALPHA; PROTEIN;

D O I：

10.3390/pathogens8040290

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The risk of developing adult T-cell leukemia/lymphoma (ATLL) in individuals infected with human T-cell lymphotropic virus 1 (HTLV-1) is about 3-5%. The mechanisms by which the virus triggers this aggressive cancer are still an area of intensive investigation. The viral protein Tax-1, together with additional regulatory proteins, in particular HTLV-1 basic leucine zipper factor (HBZ), are recognized as relevant viral factors required for both viral replication and transformation of infected cells. Tax-1 deregulates several cellular pathways affecting the cell cycle, survival, and proliferation. The effects of Tax-1 on the NF-kappa B pathway have been thoroughly studied. Recent studies also revealed the impact of Tax-1 and HBZ on microRNA expression. In this review, we summarize the recent progress in understanding the contribution of HTLV-1 Tax- and HBZ-mediated deregulation of NF-kappa B and the microRNA regulatory network to HTLV-1 pathogenesis.

引用

页数：18

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