Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro

被引：13
|
作者：
Chen, Hao [1 ]
Tang, Ben-Qin [2 ,3 ]
Chen, Li [1 ]
Liang, Jing-Yu [1 ]
Sun, Jian-Bo [1 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept Nat Med Chem, Nanjing 210009, Peoples R China
[2] Shunde Polytech, Dept Med Sci, Foshan 528333, Peoples R China
[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macau, Peoples R China
来源：
FITOTERAPIA | 2018年 / 129卷
关键词：
Ajuga decumbens; Neoclerodane diterpenoids; Phytoecdysterone; Cytotoxic activities; Superoxide anion generation; Elastase release; CLERODANE DITERPENOIDS; COLORIMETRIC ASSAY; NIPPONENSIS; NEUTROPHILS; PLANTS;
D O I：
10.1016/j.fitote.2018.06.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins K-N (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils.
引用
收藏
页码：7 / 12
页数：6
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