Localized committed differentiation of neural stem cells based on the topographical regulation effects of TiO2 nanostructured ceramics

被引：10

作者：

Mou, Xiaoning ^{[1
]}

Wang, Shu ^{[1
,2
]}

Guo, Weibo ^{[1
,2
]}

Ji, Shaozheng ^{[3
]}

Qiu, Jichuan ^{[3
]}

Li, Deshuai ^{[1
,2
]}

Zhang, Xiaodi ^{[1
,2
]}

Zhou, Jin ^{[4
,5
]}

Tang, Wei ^{[6
]}

Wang, Changyong ^{[4
,5
]}

Liu, Hong ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Natl Ctr Nanosci & Technol NCNST, Beijing 100083, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Shandong Univ, State Key Lab Crystal Mat, 27 Shandanan Rd, Jinan 250100, Peoples R China

[4] Acad Mil Med Sci, Inst Basic Med Sci, Dept Adv Interdisciplinary Studies, Beijing 100850, Peoples R China

[5] Acad Mil Med Sci, Tissue Engn Res Ctr, Beijing 100850, Peoples R China

[6] Shandong Univ, Sch Med, Dept Pathogen Biol, Jinan 250012, Peoples R China

来源：

NANOSCALE | 2016年 / 8卷 / 27期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

PROGENITOR-CELL; SURFACE; ATTACHMENT; ASTROCYTE; ADHESION;

D O I：

10.1039/c6nr01874b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, a porous-flat TiO2 micropattern was fabricated with flat and nanoporous TiO2 ceramics for investigating the effect of topography on neural stem cell (NSC) differentiation. This finding demonstrates that localized committed differentiation could be achieved in one system by integrating materials with different topographies.

引用

页码：13186 / 13191

页数：6

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