Topically Administered Gold Nanoparticles Inhibit Experimental Corneal Neovascularization in Mice

被引：33

作者：

Cho, Won-Kyung ^{[1
,2
]}

Kang, Seungbum ^{[1
,2
]}

Choi, Hyunsu ^{[2
]}

Rho, Chang Rae ^{[1
,2
]}

机构：

[1] Catholic Univ Korea, Dept Ophthalmol & Visual Sci, Daejeon St Marys Hosp, Coll Med, Taejon 301723, South Korea

[2] Catholic Univ Korea, Clin Res Inst, Daejeon St Marys Hosp, Coll Med, Taejon 301723, South Korea

来源：

CORNEA | 2015年 / 34卷 / 04期

关键词：

corneal neovascularization; gold nanoparticle; extracellular signal-regulated kinase; vascular endothelial growth factor receptor 2; ENDOTHELIAL-CELLS; GROWTH-FACTOR; BEVACIZUMAB; PATHWAYS;

D O I：

10.1097/ICO.0000000000000343

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The aim of this study was to evaluate the in vivo effects and mechanism of topically administered gold nanoparticles (AuNP) in a mouse model of corneal neovascularization. Methods: Inflammatory corneal neovascularization was induced by alkali burns, and the corneas were treated with topical AuNPs. After 1 week, the area of corneal neovascularization was measured using image analysis. The levels of vascular endothelial growth factor receptor 2 and extracellular signal-regulated kinase (ERK1/2) were evaluated by Western blotting. Results: The area of corneal neovascularization was significantly reduced by 39.8% in the AuNP group compared with the control group (P = 0.002). Corneal vascular endothelial growth factor receptor 2 level was higher in the control group than in the AuNP-treated group (P = 0.029). AuNP treatment similarly inhibited burn-induced phosphorylation of ERK (P = 0.029). Conclusions: Topical administration of AuNPs significantly reduced development of inflammatory corneal neovascularization by inhibiting the ERK pathway.

引用

页码：456 / 459

页数：4

共 18 条

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