Regiospecific preparation of 1,4,5-trisubstituted pyrazoles from 2-(1H-1,2,3-benzotriazol-1-yl)-3-(4-aryl)-2-propenals

被引：15

作者：

Katritzky, Alan R. ^{[1
]}

Vakulenko, Anatoliy V. ^{[1
]}

Akue-Gedu, Rufine ^{[1
]}

Gromova, Anna V. ^{[1
]}

Witek, Rachel ^{[1
]}

Rogers, James W. ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Compounds, Gainesville, FL 32611 USA

来源：

ARKIVOC | 2007年

关键词：

pyrazoles; regiospecific synthesis; cyclization reaction;

D O I：

10.3998/ark.5550190.0008.102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of alpha-benzotriazolyl-alpha,beta-unsaturated aldehydes with monosubstituted hydrazines followed by alkylation at the 4- position of the pyrazoline ring and elimination of the benzotriazole group affords 1,4,5- trisubstituted pyrazoles in overall yields of 52 - 79%.

引用

页码：9 / 21

页数：13

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