Readers of histone modifications

被引：399
作者：
Yun, Miyong [1 ]
Wu, Jun [1 ]
Workman, Jerry L. [2 ]
Li, Bing [1 ]
机构：
[1] UT SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[2] Stowers Med Res Inst, Kansas City, MO 64110 USA
来源：
CELL RESEARCH | 2011年 / 21卷 / 04期
基金：
美国国家卫生研究院;
关键词：
histone modification; chromatin; epigenetics; CHROMATIN MODIFICATIONS; SILENT CHROMATIN; STRUCTURAL BASIS; H3; METHYLATION; NONCODING RNA; HP1; BINDING; PHD FINGER; ACETYLATION; RECOGNITION; DNA;
D O I：
10.1038/cr.2011.42
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.
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收藏
页码：564 / 578
页数：15
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