Internet-guided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial

被引:10
作者
Leerssen, Jeanne [1 ,2 ]
Foster-Dingley, Jessica C. [1 ]
Lakbila-Kamal, Oti [1 ,2 ]
Dekkers, Laura M. S. [1 ]
Albers, Anne C. W. [1 ]
Ikelaar, Savannah L. C. [1 ]
Maksimovic, Teodora [1 ]
Wassing, Rick [1 ]
Houtman, Simon J. [1 ]
Bresser, Tom [1 ,2 ]
Blanken, Tessa F. [1 ,2 ]
te Lindert, Bart [1 ]
Ramautar, Jennifer R. [1 ]
Van Someren, Eus J. W. [1 ,2 ,3 ]
机构
[1] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci NIN, Dept Sleep & Cognit, Meibergdreef 47, NL-1105 BA Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res CNCR, Dept Integrat Neurophysiol, Amsterdam Neurosci, Amsterdam, Netherlands
[3] Vrije Univ, Amsterdam UMC, Amsterdam Neurosci, Psychiat, Amsterdam, Netherlands
基金
欧洲研究理事会;
关键词
Insomnia; Depression; Cognitive behavioral therapy for insomnia; Chronobiological therapy; Randomized controlled trial; PHYSICAL-ACTIVITY; SLEEP; METAANALYSIS; THERAPY; QUESTIONNAIRE; LIFE; VALIDATION; INVENTORY; ANXIETY; IMPACT;
D O I
10.1186/s12888-020-02554-8
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Major depressive disorder is among the most burdening and costly chronic health hazards. Since its prognosis is poor and treatment effectiveness is moderate at best, prevention would be the strategy of first choice. Insomnia may be the best modifiable risk factor. Insomnia is highly prevalent (4-10%) and meta-analysis estimates +/- 13% of people with insomnia to develop depression within a year. Among people with insomnia, recent work identified three subtypes with a particularly high lifetime risk of depression. The current randomized controlled trial (RCT) evaluates the effects of internet-guided Cognitive Behavioral Therapy for Insomnia (CBT-I), Chronobiological Therapy (CT), and their combination on insomnia and the development of depressive symptoms. Methods We aim to include 120 participants with Insomnia Disorder (ID) of one of the three subtypes that are more prone to develop depression. In a two by two factorial repeated measures design, participants will be randomized to CBT-I, CT, CBT-I + CT or treatment as usual, and followed up for one year. The primary outcome is the change, relative to baseline, of the severity of depressive symptoms integrated over four follow-ups spanning one year. Secondary outcome measures include a diagnosis of major depressive disorder, insomnia severity, sleep diaries, actigraphy, cost-effectiveness, and brain structure and function. Discussion Pre-selection of three high-risk insomnia subtypes allows for a sensitive assessment of the possibility to prevent the development and worsening of depressive symptoms through interventions targeting insomnia.
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页数:11
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