The prognostic value of long noncoding RNA MEG3 expression in the survival of patients with cancer: A meta-analysis

被引：25

作者：

Binabaj, Maryam Moradi ^{[1
,2
]}

Bahrami, Afsane ^{[2
,3
]}

Bahreyni, Amirhossein ^{[4
,5
]}

Shafiee, Mojtaba ^{[2
,6
]}

Rahmani, Farzad ^{[1
,2
]}

Khazaei, Majid ^{[7
,8
]}

Soleimanpour, Saman ^{[9
]}

Ghorbani, Elnaz ^{[10
]}

Fiuji, Hamid ^{[11
]}

Ferns, Gordon A. ^{[12
]}

Ryzhikov, Mikhail ^{[13
]}

Avan, Amir ^{[8
,14
]}

Hassanian, Seyed Mahdi ^{[1
,8
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Med Biochem, Mashhad, Iran

[2] Mashhad Univ Med Sci, Fac Med, Student Res Comm, Mashhad, Iran

[3] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjnad, Iran

[4] Mazandaran Univ Med Sci, Fac Med, Dept Clin Biochem, Sari, Mazandaran, Iran

[5] Mazandaran Univ Med Sci, Fac Med, Immunogenet Res Ctr, Sari, Mazandaran, Iran

[6] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Iran

[7] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Iran

[8] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[9] Mashhad Univ Med Sci, Sch Med, Dept Microbiol & Virol, Mashhad, Iran

[10] Al Zahra Univ, Dept Microbiol, Tehran, Iran

[11] Payame Noor Univ, Dept Biochem, Mashhad, Iran

[12] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England

[13] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA

[14] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 11期

关键词：

long noncoding RNAs (lncRNAs); maternally expressed gene 3; tumor survival; AFFECTS CELL-PROLIFERATION; BREAST-CANCER; DECREASED EXPRESSION; POOR-PROGNOSIS; DOWN-REGULATION; LNCRNA MEG3; APOPTOSIS; P53; IDENTIFICATION; SUPPRESSION;

D O I：

10.1002/jcb.27276

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (lncRNAs) play an important role in carcinogenesis and cancer progression. lncRNA maternally expressed gene 3 (MEG3) is a tumor suppressor that is downregulated in several cancers. However, its prognostic value in human malignancies remains controversial. We have therefore undertaken a meta-analysis to explore the relationship between cancer survival and the expression of lncRNA MEG3. A systematic literature search identified 13 potentially eligible investigations comprising 1733 patients in nine different cancer types. In the pooled analysis, a low expression of MEG3 was associated with low overall survival (OS) in patients with cancer having a combined hazard ratio (HR) of 0.830 (HR=0.83; 95% CI: 0.70-0.98; p=0.03; random effect model). However, subgroup analysis according to cancer type revealed that MEG3 expression was not associated with better OS in gastrointestinal cancer (HR=0.58, 95% CI=0.33-1.03; p=0.06), and patients with breast cancer (HR=0.85, 95% CI: 0.12-5.88; p=0.87). In conclusion, our results demonstrate that only in the pooled analysis, there was a significant relationship between MEG3 expression and cancer survival. Further investigation of other molecular biomarkers involved in tumorigenesis-related pathways is necessary.

引用

页码：9583 / 9590

页数：8

共 63 条

[1] The Therapeutic Potential of Targeting Tumor Microenvironment in Breast Cancer: Rational Strategies and Recent Progress [J].