Design, green synthesis, anti-microbial, and anti-oxidant activities of novel α-aminophosphonates via Kabachnik-Fields reaction

被引：24
作者：
Sampath, C. [1 ]
Harika, P. [2 ]
Revaprasadu, N. [1 ]
机构：
[1] Univ Zululand, Dept Chem, ZA-3886 Kwa Dlangezwa, Kwazulu Natal, South Africa
[2] Andhra Loyola Inst Engn & Technol, Dept Chem, Vijayawada, Andhra Pradesh, India
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2016年 / 191卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
alpha-Aminophosphonates; Kabachnik-Fields reaction; green synthesis; anti-microbial activity; anti-oxidant activity; BIOLOGICAL-ACTIVITY; AMINO PHOSPHONATES; ACID;
D O I：
10.1080/10426507.2015.1035379
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient and environmentally friendly protocol has been developed for the synthesis of novel -aminophosphonates in good to excellent yields (76-92%) by a one-pot, three-component reaction of an amine, an aldehyde, and diphenyl phosphite using polyethylene glycol (PEG-400) as a green solvent at 80 degrees C via Kabachnik-Fields reaction. Their chemical structures were elucidated by IR, H-1, C-13, and P-31 NMR spectroscopy, mass spectrometry, and elemental analysis. The titled compounds displayed moderate to high anti-microbial and anti-oxidant activities.
引用
收藏
页码：1081 / 1085
页数：5
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