Defibrotide for Sinusoidal Obstruction Syndrome and Nodular Regenerative Hyperplasia After Oxaliplatin-Based Hepatic Intra-Arterial Chemotherapy: A Case Report

被引：2

作者：

Druet, Amaury ^{[1
]}

Mosnier, Jean-Francois ^{[2
]}

Corbineau, Erwan ^{[3
]}

Matysiak-Budnik, Tamara ^{[1
]}

Touchefeu, Yann ^{[1
]}

Viala, Caroline ^{[1
]}

机构：

[1] Univ Hosp Nantes, Inst Malad Appareil Digestif, Digest Oncol Unit, 1 Pl Alexis Ricordeau, F-44093 Nantes 1, France

[2] Univ Hosp Nantes, Dept Pathol, Nantes, France

[3] Univ Hosp Nantes, Dept Pharm, Nantes, France

来源：

CLINICAL COLORECTAL CANCER | 2022年 / 21卷 / 02期

关键词：

Sinusoidal obstruction syndrome; Oxaliplatin; Intra-arterial infusion; Colorectal neoplasm; Defibrotide; COLORECTAL-CANCER; ARTERIAL INFUSION; LIVER METASTASES; RESECTION; TRIAL;

D O I：

10.1016/j.clcc.2021.10.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

• Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of oxaliplatin-based chemotherapy. • Nodular regenerative hyperplasia can be associated at a late stage of SOS, and should be suspected in case of signs of portal hypertension such as thrombocytopenia or splenomegaly. • To our knowledge, this is the first report of SOS occurring after oxaliplatin hepatic arterial infusion (HAI). • We report a case of a 43-year-old man, with colorectal liver metastases with SOS associated with nodular regenerative hyperplasia, diagnosed after 28 cycles of oxaliplatin-based HAI, treated with defibrotide but with a fatal outcome. © 2021 Elsevier Inc.

引用

页码：E98 / E101

页数：4

共 20 条

[1] Hepatic arterial infusion in the management of colorectal cancer liver metastasis: Current and future perspectives [J].

Chapelle, Nicolas ;

Matysiak-Budnik, Tamara ;

Douane, Frederic ;

Metairie, Sylvie ;

Rougier, Philippe ;

Touchefeu, Yann .

DIGESTIVE AND LIVER DISEASE, 2018, 50 (03) :220-225

[2] Toxic injury to hepatic sinusoids: Sinusoidal obstruction syndrome (veno-occlusive disease) [J].

DeLeve, LD ;

Shulman, HM ;

McDonald, GB .

SEMINARS IN LIVER DISEASE, 2002, 22 (01) :27-41

[3] Hepatic arterial oxaliplatin infusion plus intravenous chemotherapy in colorectal cancer with inoperable hepatic metastases: A trial of the Gastrointestinal Group of the Federation Nationale des Centres de Lutte Contre le Cancer [J].

Ducreux, M ;

Ychou, M ;

Laplanche, A ;

Gamelin, E ;

Lasser, P ;

Husseini, F ;

Quenet, F ;

Viret, F ;

Jacob, JH ;

Boige, V ;

Elias, D ;

Delperro, JR ;

Luboinski, M .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) :4881-4887

[4] Pharmacokinetic advantage of intra-arterial hepatic oxaliplatin administration: comparative results with cisplatin using a rabbit VX2 tumor model [J].

Dzodic, R ;

Gomez-Abuin, G ;

Rougier, P ;

Bonnay, M ;

Ardouin, P ;

Gouyette, A ;

Rixe, O ;

Ducreux, M ;

Munck, JN .

ANTI-CANCER DRUGS, 2004, 15 (06) :647-650

[5] Defibrotide in hematopoietic stem cell transplantation: A multicenter survey study of the Spanish Hematopoietic Stem Cell Transplantation Group (GETH) [J].

Gonzalez Vicent, Marta ;

Diaz de Heredia, Cristina ;

Gonzalez de Pablo, Jesus ;

Molina, Blanca ;

Regueiro, Alexandra ;

Perez Martinez, Antonio ;

Palomo, Pilar ;

Lopez Corral, Lucia ;

Garcia, Estefania ;

Fernandez, Jose Maria ;

Perez, Ariadna ;

Jimenez, Maria Jose ;

Guerreiro, Manuel ;

Vallejo, Carlos ;

Gallardo, Ana Isabel ;

Lopez, Oriana ;

Benito, Ana ;

Marsal, Julia ;

Duarte, Monica ;

Bento, Leyre ;

Badell, Isabel ;

Pedraza, Alexandra ;

Jimenez Ubieto, Ana ;

Gonzalez, Pedro ;

Gomez Centurion, Ignacio ;

Costilla, Lissette ;

Belendez, Cristina ;

Esquirol, Albert ;

Espigado, Ildefonso ;

Lavilla, Esperanza ;

Diaz, Miguel Angel .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2021, 106 (06) :842-850

[6] Sinusoidal Obstruction Syndrome and Postoperative Complications Resulting from Preoperative Chemotherapy for Colorectal Cancer Liver Metastasis [J].

Hisaka, Toru ;

Ishikawa, Hiroto ;

Sakai, Hisamune ;

Kawahara, Ryuichi ;

Goto, Yuichi ;

Nomura, Yoriko ;

Yasunaga, Masafumi ;

Kinugasa, Tetsushi ;

Fujita, Fumihiko ;

Mizobe, Tomoaki ;

Fukahori, Masaru ;

Miwa, Keisuke ;

Nakashima, Osamu ;

Tanigawa, Masahiko ;

Naito, Yoshiki ;

Akiba, Jun ;

Yano, Hirohisa ;

Tanaka, Hiroyuki ;

Akagi, Yoshito ;

Okuda, Koji .

ANTICANCER RESEARCH, 2019, 39 (08) :4549-4554

[7] Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome [J].

Kernan, Nancy A. ;

Grupp, Stephan ;

Smith, Angela R. ;

Arai, Sally ;

Triplett, Brandon ;

Antin, Joseph H. ;

Lehmann, Leslie ;

Shore, Tsiporah ;

Ho, Vincent T. ;

Bunin, Nancy ;

Iacobelli, Massimo ;

Liang, Wei ;

Hume, Robin ;

Tappe, William ;

Soiffer, Robert ;

Richardson, Paul .

BRITISH JOURNAL OF HAEMATOLOGY, 2018, 181 (06) :816-827

[8] Sinusoidal obstruction syndrome [J].

Ledinghen, Victor de ;

Villate, Alban ;

Robin, Marie ;

Decraecker, Marie ;

Valla, Dominique ;

Hillaire, Sophie ;

Hernandez-Gea, Virginia ;

Dutheil, Daniell ;

Bureau, Christophe ;

Plessier, Aurelie .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2020, 44 (04) :480-485

[9] Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV [J].

Levi, F. A. ;

Boige, V. ;

Hebbar, M. ;

Smith, D. ;

Lepere, C. ;

Focan, C. ;

Karaboue, A. ;

Guimbaud, R. ;

Carvalho, C. ;

Tumolo, S. ;

Innominato, P. ;

Ajavon, Y. ;

Truant, S. ;

Castaing, D. ;

De Baere, T. ;

Kunstlinger, F. ;

Bouchahda, M. ;

Afshar, M. ;

Rougier, P. ;

Adam, R. ;

Ducreux, M. .

ANNALS OF ONCOLOGY, 2016, 27 (02) :267-274

[10] Hepatic Arterial Infusion Chemotherapy for Unresectable Liver Metastases of Colorectal Cancer: A Multicenter Retrospective Study [J].

Lim, Annie ;

Le Sourd, Samuel ;

Senellart, Helene ;

Luet, Dominique ;

Douane, Frederic ;

Perret, Christophe ;

Bouvier, Antoine ;

Metairie, Sylvie ;

Cauchin, Estelle ;

Rougier, Philippe ;

Matysiak-Budnik, Tamara ;

Touchefeu, Yann .

CLINICAL COLORECTAL CANCER, 2017, 16 (04) :308-315

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