Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA)

被引：22

作者：

Yung, GLP

Le, TD

Roord, S

Prakken, B

Albani, S

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[3] Androclus Therapeut, San Diego, CA 92121 USA

[4] IACOPO Inst Translat Med, San Diego, CA USA

[5] Univ Chile Independencia 1027, Fac Med Norte, ICBM, Santiago, Chile

[6] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, NL-3508 Utrecht, Netherlands

来源：

INFLAMMATION RESEARCH | 2003年 / 52卷 / 11期

关键词：

D O I：

10.1007/s00011-003-1204-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rheumatoid arthritis (RA) is an inflammatory disease that primarily involves the joints and has a worldwide prevalence of about one percent, with a female to male ratio of 3:1. This chapter summarizes some of the recent progress in molecular immunology, and discusses the application of this new knowledge for therapeutic purposes. We focus on our recent experiences and that of others in modulation of antigen specific responses as a tool for manipulating autoimmune inflammation. Particular emphasis is given to the concept of exploiting for therapeutic purposes a natural mechanism of immune regulation. This mechanism is based on sequential cross recognition of bacterial and human derived heat shock protein peptides.

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页码：443 / 451

页数：9

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