Prognostic value of copeptin in patients with acute stroke

Context: There is a need to improve stroke care through the prompt identification of stroke patients at increased risk of an adverse outcome. Objective: To evaluate the prognostic value of copeptin in patients with stroke. Methods: We systematically searched PubMed and Embase for relevant studies. Poor outcome and mortality were analyzed. Results: Twelve studies, containing 2682 patients, were included. Pooled analysis showed that copeptin is an independent prognostic marker of poor outcome after acute stroke and there is a borderline effect of copeptin in predicting mortality after acute stroke. Conclusions: Copeptin is an independent predictor of poor outcome and mortality for patients with acute stroke.