Post-transcriptional regulation of gene expression in trypanosomes and leishmanias

被引：315
作者：
Clayton, Christine
Shapira, Michal
机构：
[1] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany
[2] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2007年 / 156卷 / 02期
基金：
英国惠康基金;
关键词：
trypanosoma; Leishmania; mRNA; degradation; translation;
D O I：
10.1016/j.molbiopara.2007.07.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：93 / 101
页数：9
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