Reduction in Antimicrobial Use and Resistance to Salmonella, Campylobacter, and Escherichia coli in Broiler Chickens, Canada, 2013-2019

被引：21

作者：

Huber, Laura ^{[1
,2
]}

Agunos, Agnes ^{[3
]}

Gow, Sheryl P. ^{[4
]}

Carson, Carolee A. ^{[3
]}

Van Boeckel, Thomas P. ^{[2
,5
]}

机构：

[1] Auburn Univ, Greene Hall,1130 Wire Rd,Off 271, Auburn, AL 36832 USA

[2] Swiss Fed Inst Technol, Zurich, Switzerland

[3] Publ Hlth Agcy Canada, Guelph, ON, Canada

[4] Publ Hlth Agcy Canada, Saskatoon, SK, Canada

[5] Ctr Dis Dynam Econ & Policy, Washington, DC USA

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

ANTIBIOTICS; RISK;

D O I：

10.3201/eid2709.204395

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimicrobial use contributes to the global rise of antimicrobial resistance (AMR). In 2014, the poultry industry in Canada initiated its Antimicrobial Use Reduction Strategy to mitigate AMR in the poultry sector. We monitored trends in antimicrobial use and AMR of foodborne bacteria (Salmonella, Escherichia coli, and Campylobacter) in broiler chickens during 2013 and 2019. We quantified the effect of antimicrobial use and management factors on AMR by using LASSO regression and generalized mixed-effect models. AMR in broiler chickens declined by 6%-38% after the decrease in prophylactic antimicrobial use. However, the withdrawal of individual compounds, such as cephalosporins and fluoroquinolones, prompted an increase in use of and resistance levels for other drug classes, such as aminoglycosides. Canada's experience with antimicrobial use reduction illustrates the potential for progressive transitions from conventional antimicrobial-dependent broiler production to more sustainable production with respect to antimicrobial use.

引用

页码：2434 / 2444

页数：11

共 33 条

[1] Antimicrobial Use Indices-The Value of Reporting Antimicrobial Use in Multiple Ways Using Data From Canadian Broiler Chicken and Turkey Farms [J].