Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinonnannan

被引：74
作者：
Vergne, Isabelle [1 ,2 ]
Gilleron, Martine [1 ,2 ]
Nigou, Jerome [1 ,2 ]
机构：
[1] CNRS, Inst Pharmacol & Biol Struct, Toulouse, France
[2] Univ Toulouse 3, Inst Pharmacol & Biol Struct, F-31062 Toulouse, France
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2015年 / 4卷
基金：
美国国家卫生研究院;
关键词：
lipoarabinomannan; Mycobacterium; cytokine; phagosome; apoptosis; autophagy; MANNOSE-CAPPED LIPOARABINOMANNAN; PHAGOSOME MATURATION ARREST; PRO-INFLAMMATORY ACTIVITY; DENDRITIC CELL-FUNCTION; MYO-INOSITOL ANCHOR; DC-SIGN; HUMAN MACROPHAGES; SELECTIVE RECOGNITION; ANTIGEN PRESENTATION; MULTIACYLATED FORMS;
D O I：
10.3389/fcimb.2014.00187
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lipoarabinomannan is a major immunomodulatory lipoglycan found in the cell envelope of Mycobacterium tuberculosis and related human pathogens. It reproduces several salient properties of M. tuberculosis in phagocytic cells, including inhibition of pro-inflammatory cytokine production, inhibition of phagolysosome biogenesis, and inhibition of apoptosis as well as autophagy. In this review, we present our current knowledge on lipoarabinomannan structure and ability to manipulate the endocytic pathway as well as phagocyte functions. A special focus is put on the molecular mechanisms employed and the signaling pathways hijacked. Available information is discussed in the context of M. tuberculosis pathogenesis.
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页数：9
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  • [1] Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses
    Afonso-Barroso, Antonio
    Clark, Simon O.
    Williams, Ann
    Rosa, Gustavo T.
    Nobrega, Claudia
    Silva-Gomes, Sandro
    Vale-Costa, Silvia
    Ummels, Roy
    Stoker, Neil
    Movahedzadeh, Farahnaz
    van der Ley, Peter
    Sloots, Arjen
    Cot, Marlene
    Appelmelk, Ben J.
    Puzo, Germain
    Nigou, Jerome
    Geurtsen, Jeroen
    Appelberg, Rui
    [J]. CELLULAR MICROBIOLOGY, 2013, 15 (04) : 660 - 674
  • [2] Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
    Alers, Sebastian
    Loeffler, Antje S.
    Wesselborg, Sebastian
    Stork, Bjoern
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (01) : 2 - 11
  • [3] Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages
    Anes, E
    Peyron, P
    Staali, L
    Jordao, L
    Gutierrez, MG
    Kress, H
    Hagedorn, M
    Maridonneau-Parini, I
    Skinner, MA
    Wildeman, AG
    Kalamidas, SA
    Kuehnel, M
    Griffiths, G
    [J]. CELLULAR MICROBIOLOGY, 2006, 8 (06) : 939 - 960
  • [4] The cell envelope glycoconjugates of Mycobacterium tuberculosis
    Angala, Shiva Kumar
    Belardinelli, Juan Manuel
    Huc-Claustre, Emilie
    Wheat, William H.
    Jackson, Mary
    [J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 49 (05) : 361 - 399
  • [5] The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction
    Appelmelk, B. J.
    den Dunnen, J.
    Driessen, N. N.
    Ummels, R.
    Pak, M.
    Nigou, J.
    Larrouy-Maumus, G.
    Gurcha, S. S.
    Movahedzadeh, F.
    Geurtsen, J.
    Brown, E. J.
    Smeets, M. M. Eysink
    Besra, G. S.
    Willemsen, P. T. J.
    Lowary, T. L.
    van Kooyk, Y.
    Maaskant, J. J.
    Stoker, N. G.
    van der Ley, P.
    Puzo, G.
    Vandenbroucke-Grauls, C. M. J. E.
    Wieland, C. W.
    van der Poll, T.
    Geijtenbeek, T. B. H.
    van der Sar, A. M.
    Bitter, W.
    [J]. CELLULAR MICROBIOLOGY, 2008, 10 (04) : 930 - 944
  • [6] RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM-TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES
    ARMSTRONG, JA
    HART, PD
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1971, 134 (03) : 713 - +
  • [7] Trafficking and release of mycobacterial lipids from infected macrophages
    Beatty, WL
    Rhoades, ER
    Ullrich, HJ
    Chatterjee, D
    Heuser, JE
    Russell, DG
    [J]. TRAFFIC, 2000, 1 (03) : 235 - 247
  • [8] Mannodendrimers prevent acute lung inflammation by inhibiting neutrophil recruitment
    Blattes, Emilyne
    Vercellone, Alain
    Eutamene, Helene
    Turrin, Cedric-Olivier
    Theodorou, Vassilia
    Majoral, Jean-Pierre
    Caminade, Anne-Marie
    Prandi, Jacques
    Nigou, Jerome
    Puzo, Germain
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (22) : 8795 - 8800
  • [9] Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response
    Briken, V
    Porcelli, SA
    Besra, GS
    Kremer, L
    [J]. MOLECULAR MICROBIOLOGY, 2004, 53 (02) : 391 - 403
  • [10] Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis
    Briken, Volker
    Miller, Jessica L.
    [J]. FUTURE MICROBIOLOGY, 2008, 3 (04) : 415 - 422
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