The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology

被引：137
|
作者：
Gentile, Francesco [2 ]
Ferrari, Mauro [3 ,4 ,5 ,6 ]
Decuzzi, Paolo [1 ,2 ,3 ]
机构：
[1] Politecn Bari, CEMeC, Bari, Italy
[2] Magna Graecia Univ Catanzaro, Ctr Bio Nanotechnol & Engn Med BioNEM, I-88100 Catanzaro, Italy
[3] Univ Texas Houston, Hlth Sci Ctr, Brown Fdn Inst Mol Med Prevent Human Dis, Houston, TX 77031 USA
[4] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA
[5] Rice Univ, Houston, TX 77251 USA
[6] Alliance NanoHlth, Houston, TX USA
来源：
ANNALS OF BIOMEDICAL ENGINEERING | 2008年 / 36卷 / 02期
关键词：
transport equation; nanoparticles; Casson fluid; microcirculation;
D O I：
10.1007/s10439-007-9423-6
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D-eff) depending non-linearly on the rheological parameter xi(c), the ratio between the plug and the vessel radii; and on the permeability parameters Pi and Omega; related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of xi(c) or Pi has the effect of reducing D-eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.
引用
收藏
页码：254 / 261
页数：8
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