Immunomodulatory functions of mesenchymal stem cells and possible mechanisms

被引：36
作者：
Wang, Qing [1 ,2 ]
Ding, Gang [3 ]
Xu, Xin [1 ]
机构：
[1] Shandong Univ, Sch Stomatol, Dept Implantol, Shandong Prov Key Lab Oral Biomed, Wenhua West Rd 44-1, Jinan, Shandong, Peoples R China
[2] Weifang Peoples Hosp, Dept Dent, Weifang, Shandong, Peoples R China
[3] Weifang Med Univ, Yidu Cent Hosp, Dept Stomatol, Linglongshan South Rd 4138, Qingzhou, Shandong, Peoples R China
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2016年 / 31卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Mesenchymal stem cells; Immunomodulation; Cell therapy; Regenerative medicine; MARROW STROMAL CELLS; HUMAN BONE-MARROW; SUPPRESS T-LYMPHOCYTE; HUMAN ADIPOSE-TISSUE; MEDIATED IMMUNOSUPPRESSION; INTERFERON-GAMMA; IFN-GAMMA; IN-VITRO; INHIBIT; PROLIFERATION;
D O I：
10.14670/HH-11-750
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In addition to their well-studied self-renewal capabilities and multipotent differentiation properties, mesenchymal stem cells (MSCs) have been reported to possess profound immunomodulatory functions both in vitro and in vivo. More and more studies have shown that MSCs are capable of interacting closely with almost all subsets of immune cells, such as T cells, B cells, dendritic cells, natural killer cells, macrophages, and neutrophils etc. The immunomodulatory property of MSCs may shed light on the treatment of a variety of autoimmune and inflammation-related diseases. In this article, we will review the studies on the immunomodulatory and anti-inflammatory functions of MSCs and the mechanisms responsible for the interaction between immune cells and MSCs, which could improve the development of promising approaches for cell-mediated immune therapies.
引用
收藏
页码：949 / 959
页数：11
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