Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

被引：283

作者：

Giorgi, Carlotta ^{[1
]}

Marchi, Saverio ^{[1
]}

Simoes, Ines C. M. ^{[2
]}

Ren, Ziyu ^{[3
]}

Morciano, Giampaolo ^{[1
,4
,16
]}

Perrone, Mariasole ^{[1
]}

Patalas-Krawczyk, Paulina ^{[2
]}

Borchard, Sabine ^{[5
]}

Jedrak, Paulina ^{[6
]}

Pierzynowska, Karolina ^{[6
]}

Szymanski, Jedrzej ^{[2
]}

Wang, David Q. ^{[7
]}

Portincasa, Piero ^{[8
]}

Wegrzyn, Grzegorz ^{[6
]}

Zischka, Hans ^{[5
,9
]}

Dobrzyn, Pawel ^{[2
]}

Bonora, Massimo ^{[10
,11
]}

Duszynski, Jerzy ^{[2
]}

Rimessi, Alessandro ^{[1
]}

Karkucinska-Wieckowska, Agnieszka ^{[12
]}

Dobrzyn, Agnieszka ^{[13
]}

Szabadkai, Gyorgy ^{[3
,13
,14
]}

Zavan, Barbara ^{[4
,14
]}

Oliveira, Paulo J. ^{[15
]}

Sardao, Vilma A. ^{[15
]}

Pinton, Paolo ^{[1
,4
]}

Wieckowski, Mariusz R. ^{[2
]}

机构：

[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Interdisciplinary Ctr Study Inflammat ICSI, Sect Pathol Oncol & Expt Biol,Lab Technol Adv The, Ferrara, Italy

[2] Polish Acad Sci, Nencki Inst Expt Biol, Dept Biochem, Warsaw, Poland

[3] UCL, Consortium Mitochondrial Res, Dept Cell & Dev Biol, London, England

[4] Cecilia Hosp, GVM Care & Res, I-48033 Cotignola, Ravenna, Italy

[5] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Mol Toxicol & Pharmacol, Neuherberg, Germany

[6] Univ Gdansk, Dept Mol Biol, Gdansk, Poland

[7] Albert Einstein Coll Med, Dept Med, Div Gastroenterol & Liver Dis, Marion Bessin Liver Res Ctr, Bronx, NY 10467 USA

[8] Univ Bari Aldo Moro, Sch Med, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy

[9] Tech Univ Munich, Inst Toxicol & Environm Hyg, Munich, Germany

[10] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA

[11] Albert Einstein Coll Med, Gottesman Inst Stem Cell & Regenerat Med Res, Bronx, NY 10467 USA

[12] Childrens Mem Hlth Inst, Dept Pathol, Warsaw, Poland

[13] Francis Crick Inst, London, England

[14] Univ Padua, Dept Biomed Sci, Padua, Italy

[15] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, UC Biotech, Biocant Pk, Cantanhede, Portugal

[16] Maria Pia Hosp, GVM Care & Res, Turin, Italy

来源：

MITOCHONDRIA AND LONGEVITY | 2018年 / 340卷

基金：

英国惠康基金; 欧盟地平线“2020”;

关键词：

NONALCOHOLIC-FATTY-LIVER; PERMEABILITY TRANSITION PORE; PROTEIN-KINASE-C; INDUCED OXIDATIVE STRESS; LIFE-SPAN DETERMINANT; EVANS CINNAMON RATS; ALPHA-LIPOIC ACID; HYDROGEN-PEROXIDE PRODUCTION; AMYLOID PRECURSOR PROTEIN; TERM CALORIE RESTRICTION;

D O I：

10.1016/bs.ircmb.2018.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROSemitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.

引用

页码：209 / 344

页数：136

共 808 条

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