Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack

被引:9
作者
Cernera, Gustavo [1 ,2 ]
Comegna, Marika [1 ,2 ]
Gelzo, Monica [1 ,2 ]
Savoia, Marcella [1 ]
Bruzzese, Dario [3 ]
Mormile, Mauro [4 ]
Zarrilli, Federica [1 ,2 ]
Amato, Felice [1 ,2 ]
Micco, Pierpaolo Di [5 ]
Castaldo, Giuseppe [1 ,2 ]
机构
[1] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, I-80131 Naples, Italy
[2] CEINGE Biotecnol Avanzate, I-80145 Naples, Italy
[3] Univ Napoli Federico II, Dipartimento Sanita Pubbl, I-80131 Naples, Italy
[4] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy
[5] Osped Fatebenefratelli, Dipartimento Med Interna, I-80131 Naples, Italy
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 07期
关键词
ischemic stroke; inherited thrombophilia; gene variants; genetic medicine; gene environmental interactions; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; HOMOCYSTEINE; EPIDEMIOLOGY; POLYMORPHISM; MANAGEMENT;
D O I
10.3390/medicina57070723
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention.
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页数:9
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