Synthesis of Polysubstituted Dihydropyridines by Four-Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate

被引：130

作者：

Sun, Jing ^{[1
]}

Xia, Er-Yan ^{[1
]}

Wu, Qun ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 16期

基金：

中国国家自然科学基金;

关键词：

QUINOLINE-DMAD ZWITTERION; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; DIMETHYL ACETYLENEDICARBOXYLATE; HETEROCYCLIC-COMPOUNDS; ADDITION-REACTIONS; FACILE SYNTHESIS; DIALKYL ACETYLENEDICARBOXYLATES; 1,4-DIPOLAR CYCLOADDITION; ACTIVATED ACETYLENES;

D O I：

10.1021/ol101475b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient procedure for the preparation of the polysubstituted dihydropyridines was developed through a unique four-component reaction of aromatic aldehydes, malononitrile, arylamines, and acetylenedicarboxylate in ethanol in the presence of triethylamine as a base promoter. This four-component reaction is atom-efficient, high-yielding, and applicable to a wide variety of four-component reactions.

引用

页码：3678 / 3681

页数：4

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