Subclinical atherosclerosis in primary antiphospholipid syndrome

被引：24

作者：

Margarita, Annamaria ^{[1
]}

Batuca, Joana ^{[1
]}

Scenna, Giovanna ^{[1
]}

Alves, Jose' Delgado ^{[1
]}

Lopez, Louis ^{[1
]}

Iannaccone, Luigi ^{[1
]}

Matsuura, Eiji ^{[1
]}

Ames, Paul R. J. ^{[1
]}

机构：

[1] Immunoclot Ltd, Leeds, W Yorkshire, England

来源：

AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS | 2007年 / 1108卷

关键词：

atherosclerosis; primary antiphospholipid;

D O I：

10.1196/annals.1422.050

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To test the atherosclerosis hypothesis in primary antiphospholipid syndrome (PAPS) we measured intima media thickness (IMT) of carotid arteries and other cardiovascular risk factors in 44 patients with PAPS (mean age 35 +/- 12 years), in 25 patients with inherited thrombophilia (mean age 40 +/- 10 years), and in 34 normal controls (mean age 38 +/- 11 years). The frequency of smoking, hypertension, and dyslipidemia was similar across groups. IMT was almost similar across groups at age groups below 40 years but IMT was greater in PAPS than controls at the common carotid (P = 0.01), at the bifurcation (P = 0.003), and at the internal carotid (P = 0.005) in the age group over 40 years. Atherosclerosis is a possibility in PAPS patients in their fourth decade of life or older.

引用

收藏

页码：475 / 480

页数：6

相关论文

共 13 条

[1] Premature atherosclerosis in primary antiphospholipid syndrome: preliminary data [J].

Ames, PRJ ;

Margarita, A ;

Sokoll, KB ;

Weston, M ;

Brancaccio, V .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (02) :315-317

[2] Are antiphospholipid antibodies an independent risk factor for atherosclerosis? [J].

Bilora, F ;

Boccioletti, V ;

Girolami, B ;

Zanon, E ;

Armani, M ;

Petrobelli, F ;

Girolami, A .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2002, 8 (02) :103-113

[3] ARTERIAL-WALL THICKNESS IS ASSOCIATED WITH PREVALENT CARDIOVASCULAR-DISEASE IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY [J].

BURKE, GL ;

EVANS, GW ;

RILEY, WA ;

SHARRETT, AR ;

HOWARD, G ;

BARNES, RW ;

ROSAMOND, W ;

CROW, RS ;

RAUTAHARJU, PM ;

HEISS, G .

STROKE, 1995, 26 (03) :386-391

[4] Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease [J].

Glueck, CJ ;

Lang, JE ;

Tracy, T ;

Sieve-Smith, L ;

Wang, P .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (10) :1490-+

[5] Guidelines on the investigation and management of the antiphospholipid syndrome [J].

Greaves, M ;

Cohen, H ;

Machin, SJ ;

Mackie, I .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 109 (04) :704-715

[6] Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome [J].

Jiménez, S ;

García-Criado, MA ;

Tàssies, D ;

Reverter, JC ;

Cervera, R ;

Gilabert, MR ;

Zambón, D ;

Ros, E ;

Bru, C ;

Font, J .

RHEUMATOLOGY, 2005, 44 (06) :756-761

[7]

Manzi S, 1999, ARTHRITIS RHEUM-US, V42, P51, DOI 10.1002/1529-0131(199901)42:1<51::AID-ANR7>3.0.CO

[8]

2-D

[9] Increased carotid artery intima-media thickness may be associated with stroke in primary antiphospholipid syndrome [J].

Medina, G ;

Casaos, D ;

Jara, LJ ;

Vera-Lastra, O ;

Fuentes, M ;

Barile, L ;

Salas, M .

ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 (07) :607-610

[10] International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) [J].

Miyakis, S ;

Lockshin, MD ;

Atsumi, T ;

Branch, DW ;

Brey, RL ;

Cervera, R ;

Derksen, RHWM ;

De Groot, PG ;

Koike, T ;

Meroni, PL ;

Reber, G ;

Shoenfeld, Y ;

Tincani, A ;

Vlachoyiannopoulos, PG ;

Krilis, SA .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (02) :295-306