The Ca2+-activated Cl- channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

被引：68
|
作者：
Qu, Zhiqiang [1 ,2 ]
Yao, Weicheng [3 ]
Yao, Ruyong [1 ]
Liu, Xiangping [1 ]
Yu, Kuai [4 ]
Hartzell, Criss [4 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Med Res Ctr, Qingdao 266555, Peoples R China
[2] Qingdao Univ, State Key Physiol Discipline, Qingdao 266555, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Dept Neurosurg, Qingdao 266555, Peoples R China
[4] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USA
来源：
CANCER MEDICINE | 2014年 / 3卷 / 03期
基金：
中国国家自然科学基金;
关键词：
ANO1; Ca2+-activated Cl- channel; cancer; cell proliferation; tumorigenesis; ACTIVATED CHLORIDE CHANNEL; GASTROINTESTINAL STROMAL TUMORS; NASOPHARYNGEAL CARCINOMA-CELLS; GASTRIC-CANCER CELLS; ION CHANNELS; BREAST-CANCER; TRANSCRIPTOME ANALYSIS; TRANSMEMBRANE PROTEIN; EPITHELIAL-CELLS; EXPRESSION;
D O I：
10.1002/cam4.232
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca2+-activated Cl- channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.
引用
收藏
页码：453 / 461
页数：9
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