Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth

被引：12

作者：

Kezios, Katrina ^{[1
]}

Gu, Yiwei ^{[1
]}

Liu, Xinhua ^{[2
]}

Cirillo, Piera ^{[3
]}

Tarrant, Darcy ^{[4
]}

Petreas, Myrto ^{[4
]}

Park, Jun-Soo ^{[4
]}

Cohn, Barbara ^{[3
]}

Factor-Litvak, Pam ^{[1
]}

机构：

[1] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, Room 1614,722 West 168th St, New York, NY 10032 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA

[3] Publ Hlth Inst, Child Hlth & Dev Studies, Berkeley, CA 94709 USA

[4] Calif Environm Protect Agcy, Dept Tox Subst Control, Berkeley, CA 94710 USA

来源：

REPRODUCTIVE TOXICOLOGY | 2017年 / 71卷

关键词：

Polychlorinated biphenyls; Hydroxylated PCB metabolites; Maternal smoking; Maternal thyroid hormone; Birth outcomes; Birth weight; Gestational length; THYROID-HORMONE LEVELS; POLYBROMINATED DIPHENYL ETHERS; PREGNANT FAROESE WOMEN; PRENATAL EXPOSURE; PLACENTAL-TRANSFER; CIGARETTE-SMOKING; HUMAN-SERUM; 3-MONTH-OLD INFANTS; EASTERN SLOVAKIA; WHOLE-BLOOD;

D O I：

10.1016/j.reprotox.2017.02.015

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p < 0.001) and lower levels of its parent compound, PCB118 (p = 0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316 g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：166 / 175

页数：10

共 71 条

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