Molecular glue concept solidifies

被引：43

作者：

Baek, Kheewoong ^{[1
]}

Schulman, Brenda A. ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Machines & Signaling, Martinsried, Germany

来源：

NATURE CHEMICAL BIOLOGY | 2020年 / 16卷 / 01期

关键词：

SELECTIVE DEGRADATION; STRUCTURAL BASIS;

D O I：

10.1038/s41589-019-0414-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4(DCAF15) broaden the mechanistic principles by which molecular glues target ubiquitylation.

引用

页码：2 / 3

页数：2

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