Synthesis and Analgesic Studies of Some New 2-pyrazolines

被引：24
作者：
Sridhar, S. [1 ]
Rajendraprasad, Y. [2 ]
机构：
[1] Malla Reddy Coll Pharm, Dept Pharmaceut Chem, Secunderabad, India
[2] Andhra Univ, Univ Coll Pharmaceut Sci, Vishakapatanam, India
来源：
E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 04期
关键词：
Pyrazolines; Analgesic activity; BIOLOGICAL EVALUATION;
D O I：
10.1155/2012/476989
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of 2-pyrazolines (4a-j) were synthesized by reacting chalcones (3a-j) with phenyl hydrazine in the presence of pyridine and ethanol. All these compounds were characterized by means of their IR, H-1-NMR spectral data and microanalyses. When these compounds were evaluated for analgesic activity, some of them were found to possess significant activity, when compared to standard drugs.
引用
收藏
页码：1810 / 1815
页数：6
相关论文
共 13 条
  • [1] Adel A.-H., 2007, MON CHEM, V138, P889
  • [2] Babu V. Harinadha, 2007, Indian Journal of Pharmaceutical Sciences, V69, P470
  • [3] Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents
    Bashir, Rafia
    Ovais, Syed
    Yaseen, Shafiya
    Hamid, Hinna
    Alam, M. S.
    Samim, Mohammad
    Singh, Surender
    Javed, Kalim
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (14) : 4301 - 4305
  • [4] Celecoxib - A review of its use in osteoarthritis, rheumatoid arthritis and acute pain
    Clemett, D
    Goa, KL
    [J]. DRUGS, 2000, 59 (04) : 957 - 980
  • [5] Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives
    Joshi, Ratnadeep S.
    Mandhane, Priyanka G.
    Diwakar, Santosh D.
    Dabhade, Sanjay K.
    Gill, Charansingh H.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (12) : 3721 - 3725
  • [6] Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents
    Khode, Suresh
    Maddi, Veeresh
    Aragade, Prashant
    Palkar, Mahesh
    Ronad, Pradeep Kumar
    Mamledesai, Shivalingarao
    Thippeswamy, A. H. M.
    Satyanarayana, D.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (04) : 1682 - 1688
  • [7] Luttinger D, 1984, PAIN, V18, pS159
  • [8] ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC N-ACETYL-DELTA-2-PYRAZOLINES AND DIHYDROTHIENOCOUMARINES
    MANNA, F
    CHIMENTI, F
    BOLASCO, A
    CENICOLA, ML
    DAMICO, M
    PARRILLO, C
    ROSSI, F
    MARMO, E
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (06) : 633 - 639
  • [9] Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines
    Palaska, E
    Aytemir, M
    Uzbay, IT
    Erol, D
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (06) : 539 - 543
  • [10] Synthesis and antiinflammatory activity of heterocyclic indole derivatives
    Rani, P
    Srivastava, VK
    Kumar, A
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (05) : 449 - 452
12