Synthesis and Analgesic Studies of Some New 2-pyrazolines

被引：26

作者：

Sridhar, S. ^{[1
]}

Rajendraprasad, Y. ^{[2
]}

机构：

[1] Malla Reddy Coll Pharm, Dept Pharmaceut Chem, Secunderabad, India

[2] Andhra Univ, Univ Coll Pharmaceut Sci, Vishakapatanam, India

来源：

E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 04期

关键词：

Pyrazolines; Analgesic activity; BIOLOGICAL EVALUATION;

D O I：

10.1155/2012/476989

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 2-pyrazolines (4a-j) were synthesized by reacting chalcones (3a-j) with phenyl hydrazine in the presence of pyridine and ethanol. All these compounds were characterized by means of their IR, H-1-NMR spectral data and microanalyses. When these compounds were evaluated for analgesic activity, some of them were found to possess significant activity, when compared to standard drugs.

引用

页码：1810 / 1815

页数：6

共 13 条

[1]

Adel A.-H., 2007, MON CHEM, V138, P889

[2]

Babu V. Harinadha, 2007, Indian Journal of Pharmaceutical Sciences, V69, P470

[3] Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents [J].

Bashir, Rafia ;

Ovais, Syed ;

Yaseen, Shafiya ;

Hamid, Hinna ;

Alam, M. S. ;

Samim, Mohammad ;

Singh, Surender ;

Javed, Kalim .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (14) :4301-4305

[4] Celecoxib - A review of its use in osteoarthritis, rheumatoid arthritis and acute pain [J].

Clemett, D ;

Goa, KL .

DRUGS, 2000, 59 (04) :957-980

[5] Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives [J].

Joshi, Ratnadeep S. ;

Mandhane, Priyanka G. ;

Diwakar, Santosh D. ;

Dabhade, Sanjay K. ;

Gill, Charansingh H. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (12) :3721-3725

[6] Synthesis and pharmacological evaluation of a novel series of 5-(substituted) aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents [J].

Khode, Suresh ;

Maddi, Veeresh ;

Aragade, Prashant ;

Palkar, Mahesh ;

Ronad, Pradeep Kumar ;

Mamledesai, Shivalingarao ;

Thippeswamy, A. H. M. ;

Satyanarayana, D. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (04) :1682-1688

[7]

Luttinger D, 1984, PAIN, V18, pS159

[8] ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC N-ACETYL-DELTA-2-PYRAZOLINES AND DIHYDROTHIENOCOUMARINES [J].

MANNA, F ;

CHIMENTI, F ;

BOLASCO, A ;

CENICOLA, ML ;

DAMICO, M ;

PARRILLO, C ;

ROSSI, F ;

MARMO, E .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (06) :633-639

[9] Synthesis and antidepressant activities of some 3,5-diphenyl-2-pyrazolines [J].

Palaska, E ;

Aytemir, M ;

Uzbay, IT ;

Erol, D .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (06) :539-543

[10] Synthesis and antiinflammatory activity of heterocyclic indole derivatives [J].

Rani, P ;

Srivastava, VK ;

Kumar, A .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (05) :449-452

← 1 2 →