Comparison of global left ventricular function using 20 phases with 10-phase reconstructions in multidetector-row computed tomography

To compare the measurement of global left-ventricular (LV) function parameters of 64-slice multidetector-row computed tomography (MDCT) between 20- and 10-reconstruction phases. Fifty five patients with suspected or known coronary artery disease underwent 64-slice MDCT. LV end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were measured from MDCT data sets using threshold-based volume segmentation and reconstruction at every 5% (20 phases) and 10% (10 phases) step through the R-R interval. These global functional parameters were compared to those obtained via two-dimensional transthoracic echocardiography (2D-TTE), considering the reference standard. The required time for CT data analysis was checked. Agreement for parameters of LV global function was determined using Pearson's correlation coefficient (r) and Bland-Altman analysis. LV volumes (EDV-5% 87.5 +/- A 17.1 ml, EDV-10% 87.7 +/- A 16.3 ml; ESV-5% 32.4 +/- A 10.6 ml, ESV-10% 31.9 +/- A 9.9 ml; SV-5% 55.1 +/- A 10.5 ml, SV-10% 55.8 +/- A 9.9 ml; mean +/- A SD) and EF (EF-5% 63.4 +/- A 6.2%, EF-10% 63.9 +/- A 5.8%) did not differ significantly between the 20- and 10 phase reconstructions, and evidenced good to excellent correlation (r = 0.786-0.896, all P < 0.001) with the 2D-TTE results. The mean required time for CT data analysis in the 20- and 10 phase reconstructions were 15.5 +/- A 4.0 and 7.3 +/- A 2.5 min. Within MDCT, using 10-phase image reconstruction is sufficient to evaluate LV volumes and EF, and is also more time-effective than 20-phase reconstruction.