An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

被引：35

作者：

Park, So Young ^{[1
]}

Oh, Kyung Taek ^{[2
]}

Oh, Young Taik ^{[3
]}

Nam Muk Oh ^{[1
]}

Youn, Yu Seok ^{[4
]}

Lee, Eun Seong ^{[1
]}

机构：

[1] Catholic Univ Korea, Div Biotechnol, Puchon 420743, Gyeonggi Do, South Korea

[2] Chung Ang Univ, Coll Pharm, Seoul 155756, South Korea

[3] Yonsei Univ, Coll Med, Dept Diagnost Radiol, Seoul 120752, South Korea

[4] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

PATHWAYS;

D O I：

10.1039/c2cc16087k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

引用

收藏

页码：2522 / 2524

页数：3

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