DNA Repair Mechanisms in Colorectal Carcinogenesis

被引：19
|
作者：
Michailidi, C. [1 ]
Papavassiliou, A. G. [1 ]
Troungos, C. [1 ]
机构：
[1] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece
来源：
CURRENT MOLECULAR MEDICINE | 2012年 / 12卷 / 03期
关键词：
Biomarker; colorectal carcinogenesis; DNA repair; gene polymorphism; genetic instability; genetic predisposition; NUCLEOTIDE EXCISION-REPAIR; DOUBLE-STRAND BREAKS; MLH1-93G-GREATER-THAN-A PROMOTER POLYMORPHISM; MUTY HOMOLOG HMYH; MISMATCH REPAIR; MICROSATELLITE-INSTABILITY; GENE POLYMORPHISMS; COLON-CANCER; ADJUVANT CHEMOTHERAPY; GERMLINE MUTATIONS;
D O I：
10.2174/156652412799218859
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
引用
收藏
页码：237 / 246
页数：10
相关论文
共 50 条
  • [41] Roles of DNA repair methyltransferase in mutagenesis and carcinogenesis
    Mutsuo Sekiguchi
    Kunihiko Sakumi
    Japanese Journal of Human Genetics, 1997, 42 : 389 - 399
  • [42] Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes
    Al-Shaheri, Fawaz N.
    Al-Shami, Kamal M.
    Gamal, Eshrak H.
    Mahasneh, Amjad A.
    Ayoub, Nehad M.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2020, 113
  • [43] DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis
    Basso, Daniela
    Navaglia, Filippo
    Fogar, Paola
    Zambon, Carlo-Federico
    Greco, Eliana
    Schiavon, Stefania
    Fasolo, Michela
    Stranges, Alessia
    Falda, Alessandra
    Padoan, Andrea
    Fadi, Elisa
    Pedrazzoli, Sergio
    Plebani, Mario
    CLINICA CHIMICA ACTA, 2007, 381 (01) : 50 - 55
  • [44] DNA repair mechanisms in cancer development and therapy
    Torgovnick, Alessandro
    Schumacher, Bjoern
    FRONTIERS IN GENETICS, 2015, 6
  • [45] DNA Damage by Radiopharmaceuticals and Mechanisms of Cellular Repair
    Monfared, Yousef Khazaei
    Heidari, Pedram
    Klempner, Samuel J.
    Mahmood, Umar
    Parikh, Aparna R.
    Hong, Theodore S.
    Strickland, Matthew R.
    Esfahani, Shadi A.
    PHARMACEUTICS, 2023, 15 (12)
  • [46] DNA Repair Mechanisms in Huntington's Disease
    Jonson, Ida
    Ougland, Rune
    Larsen, Elisabeth
    MOLECULAR NEUROBIOLOGY, 2013, 47 (03) : 1093 - 1102
  • [47] Resolving DNA Damage: Epigenetic Regulation of DNA Repair
    Karakaidos, Panagiotis
    Karagiannis, Dimitris
    Rampias, Theodoros
    MOLECULES, 2020, 25 (11):
  • [48] Clinical importance of DNA repair in sporadic colorectal cancer
    Laporte, Gustavo A.
    Leguisamo, Natalia M.
    Kalil, Antonio N.
    Saffi, Jenifer
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2018, 126 : 168 - 185
  • [49] The significance of DNA repair system in transformation to cancer cells in menopausal women
    Romanowicz-Makowska, Hanna
    Smolarz, Beata
    Makowski, Marcin
    Pertynski, Tomasz
    PRZEGLAD MENOPAUZALNY, 2009, 8 (01): : 26 - 32
  • [50] Molecular chaperones in DNA repair mechanisms: Role in genomic instability and proteostasis in cancer
    Hasan, Adria
    Rizvi, Suroor Fatima
    Parveen, Sana
    Mir, Snober S.
    LIFE SCIENCES, 2022, 306
12345