MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer

Objectives. Matrix metalloproteinase (MMP-7) is a secreted matrilysin, which contributes to tumor progression through breakdown of basement membranes and angiogenesis. Therefore, we aimed to investigate the association of MMP-7 -181A > G gene polymorphism with risk of cervical cancer. Methods. In the present case control study, we enrolled a total of 150 cervical cancer patients confirmed by histopathology and 162 unrelated healthy individuals. Polymorphism for MMP-7 gene (-181A > G) was genotyped by polymerase chain reaction and restriction enzyme length polymorphism. Results. Frequency of MMP-7 -181GG genotype and -181G allele differed significantly between patients with cervical cancer (29.3%) and healthy individuals (19.4%) (P=0.041; ORGG = 1.94 and P=0.048; ORG = 1.94). Individuals with MMP-7 -181GG genotype were at higher risk of stage 11 of cervical cancer with borderline significance (P=0.05, OR=2.78; 95%CI: 0.89-8.69). However, interaction of MMP-7 -181AG and GG genotypes with tobacco usage did not modulate the cervical cancer risk significantly (OR 2.21, 95% CI=0.59-8.1 and OR 3.17, 95% CI=0.64-15.7). Conclusion. Individuals with MMP-7 -181GG genotype were at significantly higher risk of cervical cancer. (C) 2008 Elsevier Inc. All rights reserved.