Bone Morphogenetic Protein-2 Signaling in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Induced by Pulsed Electromagnetic Fields
Pulsed electromagnetic fields (PEMFs) are clinically used with beneficial effects in the treatment of bone fracture healing. This is due to PEMF ability to favor the osteogenic differentiation of mesenchymal stem cells (MSCs). Previous studies suggest that PEMFs enhance the osteogenic activity of bone morphogenetic protein-2 (BMP2) which is used in various therapeutic interventions. This study investigated the molecular events associated to the synergistic activity of PEMFs and BMP2 on osteogenic differentiation. To this aim, human MSCs (hMSCs) were exposed to PEMFs (75 Hz, 1.5 mT) in combination with BMP2, upon detection of the minimal dose able to induce differentiation. Changes in the expression of BMP signaling pathway genes including receptors and ligands, as well as in the phosphorylation of BMP downstream signaling proteins, such as SMAD1/5/8 and MAPK, were analyzed. Results showed the synergistic activity of PEMFs and BMP2 on osteogenic differentiation transcription factors and markers. The PEMF effects were associated to the increase in BMP2, BMP6, and BMP type I receptor gene expression, as well as SMAD1/5/8 and p38 MAPK activation. These results increase knowledge concerning the molecular events involved in PEMF stimulation showing that PEMFs favor hMSCs osteogenic differentiation by the modulation of BMP signaling components.
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Yang, Xiao
Wang, Ya-ping
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Wang, Ya-ping
Liu, Feng-xiang
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Div Surg, Shanghai 200030, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Liu, Feng-xiang
Zeng, Ke
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Zeng, Ke
Qian, Ming-quan
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Qian, Ming-quan
Chen, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Chen, Gang
Shi, Lei
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
Shi, Lei
Zhu, Guo-xing
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R ChinaNanjing Med Univ, Peoples Hosp Wuxi 2, Div Orthoped, Wuxi 214000, Peoples R China
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Huang, Jianghong
Wang, Daming
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R China
Shenzhen Longer3d Technol, Software Town Shenzhen Univ, Shenzhen, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Wang, Daming
Chen, Jielin
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Chen, Jielin
Liu, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Liu, Wei
Duan, Li
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Duan, Li
You, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
You, Wei
Zhu, Weimin
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Zhu, Weimin
Xiong, Jianyi
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Xiong, Jianyi
Wang, Daping
论文数: 0引用数: 0
h-index: 0
机构:
Shenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Key Lab Tissue Engn, Shenzhen 518035, Peoples R China
Shenzhen Second Peoples Hosp, Shenzhen Lab Digital Orthoped Engn, Shenzhen 518035, Peoples R ChinaShenzhen Second Peoples Hosp, Shenzhen Natl Key Dept Orthoped, Shenzhen 518035, Peoples R China
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Complejo Hosp Univ Ntra, Serv Cirugia Ortoped & Traumatol, Santa Cruz De Tenerife, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Vayas, Raquel
Reyes, Ricardo
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Ctr Biomed Res Canary Isl, Inst Biomed Technol, San Cristobal la Laguna, Spain
Univ La Laguna, Dept Biochem Microbiol Cell Biol & Genet, San Cristobal la Laguna, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Reyes, Ricardo
Arnau, Maria Rosa
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Serv Estabulario & Anim Ario Serv Gen Apoyo Inves, San Cristobal la Laguna, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Arnau, Maria Rosa
Evora, Carmen
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Univ La Laguna, Ctr Biomed Res Canary Isl, Inst Biomed Technol, San Cristobal la Laguna, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Evora, Carmen
Delgado, Araceli
论文数: 0引用数: 0
h-index: 0
机构:
Univ La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
Univ La Laguna, Ctr Biomed Res Canary Isl, Inst Biomed Technol, San Cristobal la Laguna, SpainUniv La Laguna, Dept Chem Engn & Pharmaceut Technol, San Cristobal la Laguna, Spain
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Tokyo Med & Dent Univ, Global Ctr Excellence GCOE Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Yuasa, Masato
Yamada, Tsuyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Tokyo Med & Dent Univ, Global Ctr Excellence GCOE Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Yamada, Tsuyoshi
Taniyama, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Taniyama, Takashi
Masaoka, Tomokazu
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Masaoka, Tomokazu
Wei Xuetao
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Wei Xuetao
Yoshii, Toshitaka
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Yoshii, Toshitaka
Horie, Masaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Univ Hosp Med, Hyperbar Med Ctr, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Horie, Masaki
Yasuda, Hiroaki
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Yasuda, Hiroaki
Uemura, Toshimasa
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Adv Ind Sci & Technol, Tsukuba, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Uemura, Toshimasa
Okawa, Atsushi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Tokyo Med & Dent Univ, Global Ctr Excellence GCOE Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Okawa, Atsushi
Sotome, Shinichi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan
Tokyo Med & Dent Univ, Grad Sch, Dept Orthopaed Res & Dev, Tokyo, JapanTokyo Med & Dent Univ, Grad Sch, Dept Orthopaed & Spinal Surg, Tokyo, Japan