Primary Sjogren Syndrome Manifested as Localized Cutaneous Nodular Amyloidosis

被引：19

作者：

Wey, Shiow-Jiuan ^{[2
]}

Chen, Yi-Ming ^{[1
,3
]}

Lai, Po-Ju ^{[2
]}

Chen, Der-Yuan ^{[1
,3
,4
]}

机构：

[1] Taichung Vet Gen Hosp, Div Allergy Immunol & Rheumatol, Taichung, Taiwan

[2] Chung Shan Med Univ Hosp, Sch Med, Dept Dermatol, Taichung, Taiwan

[3] Natl Yang Ming Univ, Fac Med, Taipei 112, Taiwan

[4] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

来源：

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY | 2011年 / 17卷 / 07期

关键词：

localized cutaneous nodular amyloidosis; Sjogren syndrome; immunoglobulin; light chain; OF-THE-LITERATURE;

D O I：

10.1097/RHU.0b013e31823209ba

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Localized cutaneous nodular amyloidosis (LCNA) is the rarest type of cutaneous amyloidosis. Typically presenting as waxy nodules on the lower extremities, it demonstrates localized deposition of AL-type amyloid in immunohistologic study and is often associated with focal plasma cell proliferation. Sjogren syndrome, an autoimmune lymphoproliferative disorder, is characterized by keratoconjunctivitis sicca and xerostomia with lymphocytic infiltration of exocrine glands. As shown in case reports, the association of LCNA with Sjogren syndrome is considerable. Herein, we report a 78-year-old woman with LCNA, who was further surveyed and diagnosed with Sjogren syndrome. In light of the significant relation between these 2 diseases, further examination for coexistence of Sjogren syndrome in addition to systemic amyloidosis is well warranted. Prompt identification of an underlying Sjogren syndrome in LCNA with polyclonal immunoglobulin amyloid may have important therapeutic consequences.

引用

页码：368 / 370

页数：3