Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage

被引：5

作者：

Arnaud, Francoise ^{[1
,2
]}

Scultetus, Anke H. ^{[1
,2
]}

Kim, Bobby ^{[1
]}

Haque, Ashraful ^{[1
]}

Saha, Biswajit ^{[1
]}

Nigam, Savita ^{[1
]}

Moon-Massat, Paula ^{[1
]}

Auker, Charles ^{[1
]}

McCarron, Richard ^{[1
,2
]}

Freilich, Daniel ^{[1
,2
]}

机构：

[1] Naval Med Res Ctr NMRC, NeuroTrauma Dept, Silver Spring, MD 20910 USA

[2] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2011年 / 39卷 / 04期

关键词：

Nitric oxide donors; blood pressure; pre-clinical resuscitation; trauma; CROSS-LINKED HEMOGLOBIN; SICKLE-CELL-DISEASE; RED-BLOOD-CELL; OXYGEN CARRIER; DEFINITIVE CARE; OXIDE; RESUSCITATION; SHOCK; VASODILATION; SUBSTITUTES;

D O I：

10.3109/10731199.2010.533126

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 mu mol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 mu mol/kg NaNO(2) seems an acceptable dose for further investigation.

引用

页码：195 / 205

页数：11

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