National Kidney Foundation Laboratory Engagement Working Group Recommendations for Implementing the CKD-EPI 2021 Race-Free Equations for Estimated Glomerular Filtration Rate: Practical Guidance for Clinical Laboratories

被引：126

作者：

Miller, W. Greg ^{[1
]}

Kaufman, Harvey W. ^{[2
]}

Levey, Andrew S. ^{[3
]}

Straseski, Joely A. ^{[4
]}

Wilhelms, Kelly W. ^{[5
]}

Yu, Hoi-Ying Elsie ^{[6
]}

Klutts, J. Stacey ^{[7
]}

Hilborne, Lee H. ^{[2
]}

Horowitz, Gary L. ^{[3
]}

Lieske, John ^{[8
]}

Ennis, Jennifer L. ^{[9
]}

Bowling, James L. ^{[10
]}

Lewis, Mary J. ^{[11
]}

Montgomery, Elizabeth ^{[11
]}

Vassalotti, Joseph A. ^{[12
]}

Inker, Lesley A. ^{[3
]}

机构：

[1] Virginia Commonwealth Univ, Richmond, VA USA

[2] Quest Diagnost, Secaucus, NJ USA

[3] Tufts Med Ctr, Boston, MA 02111 USA

[4] ARUP Labs, Salt Lake City, UT USA

[5] Sonora Quest Labs, Phoenix, AZ USA

[6] Geisinger Hlth Syst, Danville, PA USA

[7] VA Cent Iowa Hlth Syst, Des Moines, IA USA

[8] Mayo Clin, Rochester, MN USA

[9] Labcorp, Chicago, IL USA

[10] Labcorp, Burlington, NC USA

[11] Natl Kidney Fdn, New York, NY USA

[12] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

来源：

CLINICAL CHEMISTRY | 2022年 / 68卷 / 04期

关键词：

creatinine; cystatin C; eGFR; estimated glomerular filtration rate; chronic kidney disease; PRACTICE GUIDELINE; SERUM CREATININE; GFR; PERFORMANCE; INCLUSION; DISEASE;

D O I：

10.1093/clinchem/hvab278

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Recognizing that race is a social and not a biological construct, healthcare professionals and the public have called for removal of race in clinical algorithms. In response, the National Kidney Foundation and the American Society of Nephrology created the Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Diseases to examine the issue and provide recommendations. The final report from the Task Force recommends calculating estimated glomerular filtration rate (eGFR) without a race coefficient using the recently published CKD-EPI 2021 creatinine (cr) and creatinine-cystatin C (cr-cys) equations. The Task Force recommends immediately replacing older eGFR(cr) equations (MDRD Study and CKD-EPI 2009) with the new CKD-EPI 2021 equation. In a 2019 survey by the College of American Pathologists, 23% of 6200 laboratories reporting eGFR(cr) used an incorrect equation that is not suitable for use with standardized creatinine measurements, 34% used the CKD-EPI 2009 equation and 43% used the MDRD Study 2006 equation re-expressed for standardized creatinine measurement. Rapid transition to using the CKD-EPI 2021 equation is an opportunity for laboratories to standardize to a single equation to eliminate differences in eGFR(cr) due to different equations used by different laboratories, and to report eGFR without use of race. We provide guidance to laboratories for implementing the CKD-EPI 2021 equations for both eGFR(cr) and eGFR(cr-cys).

引用

页码：511 / 520

页数：10

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