Uncovering the Neural Bases of Cognitive and Affective Empathy Deficits in Alzheimer's Disease and the Behavioral-Variant of Frontotemporal Dementia

被引:127
作者
Dermody, Nadene [1 ,2 ]
Wong, Stephanie [2 ,4 ]
Ahmed, Rebekah [2 ,5 ]
Piguet, Olivier [2 ,3 ,4 ]
Hodges, John R. [2 ,3 ,4 ]
Irish, Muireann [1 ,2 ,4 ]
机构
[1] Univ New South Wales, Sch Psychol, Sydney, NSW, Australia
[2] Neurosci Res Australia, Sydney, NSW, Australia
[3] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
[4] Australian Res Council Ctr Excellence Cognit & It, Sydney, NSW, Australia
[5] Univ New South Wales, Fac Med, Prince Wales Clin Sch, Sydney, NSW, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
Neurodegenerative diseases; orbitofrontal cortex; right hemisphere; social cognition; theory of mind; EPISODIC FUTURE THINKING; VOXEL-BASED MORPHOMETRY; ANTERIOR TEMPORAL-LOBE; SOCIAL COGNITION; SEMANTIC DEMENTIA; NEURODEGENERATIVE DISEASE; DOUBLE DISSOCIATION; FRONTAL VARIANT; SELF-AWARENESS; IMPAIRMENT;
D O I
10.3233/JAD-160175
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Loss of empathy is a core presenting feature of the behavioral-variant of frontotemporal dementia (bvFTD), resulting in socioemotional difficulties and behavioral transgressions. In contrast, interpersonal functioning remains relatively intact in Alzheimer's disease (AD), despite marked cognitive decline. The neural substrates mediating these patterns of loss and sparing in social functioning remain unclear, yet are relevant for our understanding of the social brain. We investigated cognitive versus affective aspects of empathy using the Interpersonal Reactivity Index (IRI) in 25 AD and 24 bvFTD patients and contrasted their performance with 22 age-and education-matched controls. Cognitive empathywas comparably compromised inADand bvFTD, whereas affective empathy was impaired exclusively in bvFTD. While controlling for overall cognitive dysfunction ameliorated perspective-taking deficits in AD, empathy loss persisted across cognitive and affective domains in bvFTD. Voxelbased morphometry analyses revealed divergent neural substrates of empathy loss in each patient group. Perspective-taking deficits correlated with predominantly left-sided temporoparietal atrophy in AD, whereas widespread bilateral frontoinsular, temporal, parietal, and occipital atrophy was implicated in bvFTD. Reduced empathic concern in bvFTD was associated with atrophy in the left orbitofrontal, inferior frontal, and insular cortices, and the bilateral mid-cingulate gyrus. Our findings suggest that social cognitive deficits in AD arise largely as a consequence of global cognitive dysfunction, rather than a loss of empathy per se. In contrast, loss of empathy in bvFTD reflects the deterioration of a distributed network of frontoinsular and temporal structures that appear crucial for monitoring and processing social information.
引用
收藏
页码:801 / 816
页数:16
相关论文
共 87 条
[1]   Theory of mind ability in the behavioural variant of frontotemporal dementia: An analysis of the neural, cognitive, and social levels [J].
Adenzato, Mauro ;
Cavallo, Marco ;
Enrici, Ivan .
NEUROPSYCHOLOGIA, 2010, 48 (01) :2-12
[2]   Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[3]  
Andersson JLR., 2010, FMRIB technical report TR07JA2
[4]  
[Anonymous], 2007, TR07JA1 FMRIB
[5]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[6]   Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia [J].
Baez, Sandra ;
Morales, Juan P. ;
Slachevsky, Andrea ;
Torralva, Teresa ;
Matus, Cristian ;
Manes, Facundo ;
Ibanez, Agustin .
CORTEX, 2016, 75 :20-32
[7]   Primary empathy deficits in frontotemporal dementia [J].
Baez, Sandra ;
Manes, Facundo ;
Huepe, David ;
Torralva, Teresa ;
Fiorentino, Natalia ;
Richter, Fabian ;
Huepe-Artigas, Daniela ;
Ferrari, Jesica ;
Montanes, Patricia ;
Reyes, Pablo ;
Matallana, Diana ;
Vigliecca, Nora S. ;
Decety, Jean ;
Ibanez, Agustin .
FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
[8]   Social Cognition Deficits: The Key to Discriminate Behavioral Variant Frontotemporal Dementia from Alzheimer's Disease Regardless of Amnesia? [J].
Bertoux, Maxime ;
de Souza, Leonardo Cruz ;
O'Callaghan, Claire ;
Greve, Andrea ;
Sarazin, Marie ;
Dubois, Bruno ;
Hornberger, Michael .
JOURNAL OF ALZHEIMERS DISEASE, 2016, 49 (04) :1065-1074
[9]  
Burgess P. W., 1997, The Hayling and Brixton tests
[10]   Affective mentalizing and brain activity at rest in the behavioral variant of frontotemporal dementia [J].
Caminiti, Silvia P. ;
Canessa, Nicola ;
Cerami, Chiara ;
Dodich, Alessandra ;
Crespi, Chiara ;
Iannaccone, Sandro ;
Marcone, Alessandra ;
Falini, Andrea ;
Cappa, Stefano F. .
NEUROIMAGE-CLINICAL, 2015, 9 :484-497