Repetitive transcranial magnetic stimulation (rTMS) improves movement-related cortical potentials in autism spectrum disorders

被引:47
作者
Enticott, Peter G. [2 ,3 ]
Rinehart, Nicole J. [3 ]
Tonge, Bruce J. [3 ]
Bradshaw, John L. [3 ]
Fitzgerald, Paul B. [1 ,2 ]
机构
[1] The Alfred, MAPrc, Melbourne, Vic 3004, Australia
[2] Monash Univ, Sch Psychol & Psychiat, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia
[3] Monash Univ, Sch Psychol & Psychiat, Ctr Dev Psychiat & Psychol, Clayton, Vic, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
autism; Asperger's disorder; supplementary motor area; EEG; rTMS; SUPPLEMENTARY-MOTOR-AREA; HIGH-FUNCTIONING AUTISM; HIGH-FREQUENCY RTMS; PARKINSONS-DISEASE; ASPERGERS-DISORDER; CHILDHOOD AUTISM; GAIT FUNCTION; EXCITABILITY; PERFORMANCE; CEREBELLAR;
D O I
10.1016/j.brs.2011.02.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background Motor impairments are common in autism spectrum disorders (ASD). Electrophysiologic studies reveal abnormalities in the preparation of movement; repetitive transcranial magnetic stimulation (rTMS) to key motor cortical sites may therefore be a useful technique for improving motor function in ASD. Objective To examine whether rTMS can improve electrophysiologic and behavioral indices of motor activity. Methods Eleven participants with ASD completed three sessions in which they were administered one of three rTMS conditions (left MI, supplementary motor area [SMA], sham) at 1 Hz for 15 minutes. Movement-related cortical potentials (MRCPs) were assessed before and after rTMS. Results rTMS to the SMA was associated with a gradient increase to the early component of MRCPs, whereas rTMS to left MI produced a stronger gradient in the late component. Conclusions rTMS appears to improve movement-related electrophysiologic activity in ASD, perhaps through an influence on cortical inhibitory processes. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:30 / 37
页数:8
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