Synthesis and Hydration Behavior of a Hydrolysis-Resistant Quasi-Choline Phosphate Zwitterionic Polymer

被引：16
|
作者：
Mukai, Masaru [1 ]
Ihara, Daiki [2 ]
Chu, Chien-Wei [1 ]
Cheng, Chao-Hung [2 ]
Takahara, Atsushi [1 ,2 ]
机构：
[1] Kyushu Univ, Inst Mat Chem & Engn, Fukuoka 8190395, Japan
[2] Kyushu Univ, Grad Sch Engn, Fukuoka 8190395, Japan
来源：
BIOMACROMOLECULES | 2020年 / 21卷 / 06期
关键词：
POLY(2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE); PHOSPHOLIPID POLYMERS; SURFACE; WATER; COPOLYMERS; ADHESION;
D O I：
10.1021/acs.biomac.0c00120
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A hydrolysis-resistant polymer bearing new quasi-choline phosphate (quasi-CP) structures as side groups, poly(2-methacryloyloxyethyl choline methylphosphonate) (PMCPm), was designed and synthesized. Radical polymerization and sub-surface-initiated radical polymerization were used to prepare homopolymer and polymer brush on polymer substrates. Hydrolytic stability and hydrophilicity of the polymer were confirmed by nuclear magnetic resonance and contact angle measurements. Furthermore, the hydration states were investigated using Fourier-transform infrared spectroscopy and differential scanning calorimetry. The similar hydration behavior of PMCPm to poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) sheds light on understanding the interfacial functions of quasi-CP-bearing zwitterionic biomaterials.
引用
收藏
页码：2125 / 2131
页数：7
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