Effects of intrathecal baclofen on daily care in children with secondary generalized dystonia: A pilot study

被引：15

作者：

Bonouvrie, Laura A. ^{[2
]}

van Schie, Petra E. M. ^{[2
]}

Becher, Jules G. ^{[2
]}

van Ouwerkerk, Willem J. R. ^{[3
]}

Reeuwijk, Alexander ^{[2
]}

Vermeulen, R. Jeroen ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Child Neurol, Med Ctr, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Dept Rehabil Med, Med Ctr, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Dept Neurosurg, Med Ctr, NL-1007 MB Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2011年 / 15卷 / 06期

关键词：

Secondary dystonia; Dyskinesia; Cerebral palsy; Intrathecal baclofen; Care giving; DYSKINETIC CEREBRAL-PALSY; MOVEMENT-DISORDERS; SPASTICITY; INFUSION; EUROPE;

D O I：

10.1016/j.ejpn.2011.05.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: Treatment options for dystonic cerebral palsy (CP) are limited. Our aims were to determine whether intrathecal baclofen (ITB) improves daily care, decreases dystonia and decreases pain in patients with dystonic CP. Methods: Patients received randomized blinded treatment with ITB or placebo. Scores on problems of daily care were recorded and dystonia, pain and comfort were assessed. Results: Four patients (three males, average age 12 years 6 months) were included (all Gross Motor Function Classification System level V). During the trial period problem scores and dystonia scores decreased in all four patients. Conclusion: In this pilot study we report positive functional effects of ITB trial treatment in four patients with dystonic CP. A randomized trial with a larger cohort is needed to verify these results. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：539 / 543

页数：5

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