A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin

被引：40
作者：
Li, Fei [1 ]
He, Jinlin [1 ]
Zhang, Mingzu [1 ]
Ni, Peihong [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou Key Lab Macromol Design & Precis Synth, Jiangsu Key Lab Adv Funct Polymer Design & Applic, Suzhou 215123, Peoples R China
来源：
POLYMER CHEMISTRY | 2015年 / 6卷 / 28期
基金：
中国国家自然科学基金;
关键词：
BLOCK-COPOLYMER HYDROGELS; DRUG-DELIVERY; POLYPRODRUG AMPHIPHILES; FACILE SYNTHESIS; RELEASE; MICELLES; PROGRESS; DESIGN; DRIVEN;
D O I：
10.1039/c5py00620a
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
An acid-labile and PEGylated polyphosphoester-doxorubicin prodrug (PBYP-g-PEG-g-DOX) was prepared via a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry. The resulting multifunctional prodrug was then used to interact with alpha-cyclodextrin (alpha-CD) to fabricate a novel supramolecular hydrogel based on inclusion complexation.
引用
收藏
页码：5009 / 5014
页数：6
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