Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza

被引：71
|
作者：
Ming, Qianliang [1 ]
Han, Ting [1 ]
Li, Wenchao [1 ]
Zhang, Qiaoyan [1 ]
Zhang, Hong [1 ]
Zheng, Chengjian [1 ]
Huang, Fang [1 ]
Rahman, Khalid [2 ]
Qin, Luping [1 ]
机构：
[1] Second Mil Med Univ, Dept Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China
[2] Liverpool John Moores Univ, Fac Sci, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England
来源：
PHYTOMEDICINE | 2012年 / 19卷 / 3-4期
关键词：
Salvia miltiorrhiza Bunge; Endophytic fungus; Trichoderma atroviride; Tanshinones; CANCER; CELLS; APOPTOSIS; INDUCTION; GROWTH;
D O I：
10.1016/j.phymed.2011.09.076
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In this study the isolation of an endophytic fungus from the root of the medicinal herb Salvia miltiorrhiza Bunge is reported for the first time. The fungus produced tanshinone I and tanshinone IIA in rich mycological medium (potato dextrose broth) under shake flask and bench scale fermentation conditions. The fungus was identified as Trichoderma atroviride by its morphology and authenticated by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Tanshinone I and tanshinone HA were identified by HPLC and LC-HRMS/MS and confirmed through comparison with authentic standards. This endophytic fungus has significant scientific and industrial potential to meet the pharmaceutical demands for tanshinone I and tanshinone HA in a cost-effective, easily accessible and reproducible way. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：330 / 333
页数：4
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