Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza

被引：74
作者：
Ming, Qianliang [1 ]
Han, Ting [1 ]
Li, Wenchao [1 ]
Zhang, Qiaoyan [1 ]
Zhang, Hong [1 ]
Zheng, Chengjian [1 ]
Huang, Fang [1 ]
Rahman, Khalid [2 ]
Qin, Luping [1 ]
机构：
[1] Second Mil Med Univ, Dept Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China
[2] Liverpool John Moores Univ, Fac Sci, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside, England
来源：
PHYTOMEDICINE | 2012年 / 19卷 / 3-4期
关键词：
Salvia miltiorrhiza Bunge; Endophytic fungus; Trichoderma atroviride; Tanshinones; CANCER; CELLS; APOPTOSIS; INDUCTION; GROWTH;
D O I：
10.1016/j.phymed.2011.09.076
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In this study the isolation of an endophytic fungus from the root of the medicinal herb Salvia miltiorrhiza Bunge is reported for the first time. The fungus produced tanshinone I and tanshinone IIA in rich mycological medium (potato dextrose broth) under shake flask and bench scale fermentation conditions. The fungus was identified as Trichoderma atroviride by its morphology and authenticated by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Tanshinone I and tanshinone HA were identified by HPLC and LC-HRMS/MS and confirmed through comparison with authentic standards. This endophytic fungus has significant scientific and industrial potential to meet the pharmaceutical demands for tanshinone I and tanshinone HA in a cost-effective, easily accessible and reproducible way. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：330 / 333
页数：4
相关论文
共 15 条
[1]  
Bi HC, 2008, XENOBIOTICA, V38, P185, DOI [10.1080/00498250701767675, 10.1080/00498250701767675 ]
[2]  
Chan P., 2009, BASED COMPLEMENT ALT, V1-8
[3]   Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit [J].
Fang, Zhi-Yuan ;
Lin, Rong ;
Yuan, Bing-Xiang ;
Yang, Guang-De ;
Liu, Yu ;
Zhang, Hui .
JOURNAL OF ETHNOPHARMACOLOGY, 2008, 115 (02) :217-222
[4]   A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights [J].
Gao, Wei ;
Hillwig, Matthew L. ;
Huang, Luqi ;
Cui, Guanghong ;
Wang, Xueyong ;
Kong, Jianqiang ;
Yang, Bin ;
Peters, Reuben J. .
ORGANIC LETTERS, 2009, 11 (22) :5170-5173
[5]   Tanshinone II A: a Potent, Natural Anti-carcinogenic Agent for the Management of Systemic Malignancies [J].
Kapoor, Shailendra .
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2009, 15 (02) :153-153
[6]   Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells [J].
Kim, JY ;
Kim, KM ;
Nan, JX ;
Zhao, YZ ;
Park, PH ;
Lee, SJ ;
Sohn, DH .
PHARMACOLOGY & TOXICOLOGY, 2003, 92 (04) :195-200
[7]   An Endophytic Fungus from Camptotheca acuminata That Produces Camptothecin and Analogues [J].
Kusari, Souvik ;
Zuehlke, Sebastian ;
Spiteller, Michael .
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (01) :2-7
[8]   Anticancer effects of tanshinone I in human non-small cell lung cancer [J].
Lee, Chen-Yu ;
Sher, Hui-Fang ;
Chen, Huei-Wen ;
Liu, Chun-Chi ;
Chen, Ching-Hsien ;
Lin, Choun-Sea ;
Yang, Pan-Chyr ;
Tsay, Hsin-Sheng ;
Chen, Jeremy J. W. .
MOLECULAR CANCER THERAPEUTICS, 2008, 7 (11) :3527-3538
[9]   A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinfiammatory mediator, high mobility group box 1 [J].
Li, Wei ;
Li, Jianhua ;
Ashok, Mala ;
Wu, Rongqian ;
Chen, Dazhi ;
Yang, Lihong ;
Yang, Huan ;
Tracey, Kevin J. ;
Wang, Ping ;
Soma, Andrew E. ;
Wang, Haichao .
JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3856-3864
[10]   Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro [J].
Liu, Jia-Jun ;
Liu, Wen-Da ;
Yang, Hong-Zhi ;
Zhang, Yong ;
Fang, Zhi-Gang ;
Liu, Pei-Qing ;
Lin, Dong-Jun ;
Xiao, Ruo-Zhi ;
Hu, Yuan ;
Wang, Chun-Zhi ;
Li, Xu-Dong ;
He, Yi ;
Huang, Ren-Wei .
ANNALS OF HEMATOLOGY, 2010, 89 (11) :1089-1097
12