Piperazine Heterocycles as Potential Anticancer Agents: A Review

被引：46
作者：
Al-Ghorbani, Mohammed [1 ,2 ]
Gouda, Moustafa A. [1 ,3 ]
Baashen, Mohammed [4 ]
Alharbi, Osama [1 ]
Almalki, Faisal A. [5 ]
Ranganatha, Lakshmi V. [6 ]
机构：
[1] Taibah Univ, Ulla Sci & Arts Coll, Dept Chem, Madinah Mnoora, Saudi Arabia
[2] Univ Thamar, Dept Chem, Coll Educ, Thamar, Yemen
[3] Mansoura Univ, Dept Chem, Fac Sci, El Gomhoria St, Mansoura, Egypt
[4] Shaqra Univ, Dept Chem, Sci & Humanities Coll, Shaqra, Saudi Arabia
[5] Umm AlQura Univ, Fac Pharm, Dept Pharmaceut Chem, Mecca 21955, Saudi Arabia
[6] Natl Inst Engn, Dept Chem, Mysore 570008, Karnataka, India
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2022年 / 56卷 / 01期
关键词：
anticancer; anti-proliferative; piperazine; heterocyclic compounds; structure-activity relationship; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; INDUCE APOPTOSIS; DERIVATIVES; ANALOGS; INHIBITORS;
D O I：
10.1007/s11094-022-02597-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health afflictions worldwide. Molecular hybridization is related to a combination of two or more pharmacophores of bioactive frames which generate a single molecular structure with enhanced activity. Previous studies described the piperazine framework as a central structure in numerous synthetic and natural compounds, showing a wide range of biological activities. Here, we review, highlight and discuss a detailed account of the anticancer applications of some important piperazine-containing hybrid heterocycles; we have also included several patents approved for the anticancer activity of piperazine heterocycles.
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收藏
页码：29 / 37
页数：9
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