Piperazine Heterocycles as Potential Anticancer Agents: A Review

被引：46

作者：

Al-Ghorbani, Mohammed ^{[1
,2
]}

Gouda, Moustafa A. ^{[1
,3
]}

Baashen, Mohammed ^{[4
]}

Alharbi, Osama ^{[1
]}

Almalki, Faisal A. ^{[5
]}

Ranganatha, Lakshmi V. ^{[6
]}

机构：

[1] Taibah Univ, Ulla Sci & Arts Coll, Dept Chem, Madinah Mnoora, Saudi Arabia

[2] Univ Thamar, Dept Chem, Coll Educ, Thamar, Yemen

[3] Mansoura Univ, Dept Chem, Fac Sci, El Gomhoria St, Mansoura, Egypt

[4] Shaqra Univ, Dept Chem, Sci & Humanities Coll, Shaqra, Saudi Arabia

[5] Umm AlQura Univ, Fac Pharm, Dept Pharmaceut Chem, Mecca 21955, Saudi Arabia

[6] Natl Inst Engn, Dept Chem, Mysore 570008, Karnataka, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2022年 / 56卷 / 01期

关键词：

anticancer; anti-proliferative; piperazine; heterocyclic compounds; structure-activity relationship; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; INDUCE APOPTOSIS; DERIVATIVES; ANALOGS; INHIBITORS;

D O I：

10.1007/s11094-022-02597-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health afflictions worldwide. Molecular hybridization is related to a combination of two or more pharmacophores of bioactive frames which generate a single molecular structure with enhanced activity. Previous studies described the piperazine framework as a central structure in numerous synthetic and natural compounds, showing a wide range of biological activities. Here, we review, highlight and discuss a detailed account of the anticancer applications of some important piperazine-containing hybrid heterocycles; we have also included several patents approved for the anticancer activity of piperazine heterocycles.

引用

页码：29 / 37

页数：9

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