The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

被引:12
作者
Aloisi, Massimo [1 ]
Rossi, Gianna [1 ]
Colafarina, Sabrina [1 ]
Guido, Maurizio [1 ]
Cecconi, Sandra [1 ]
Poma, Anna M. G. [1 ]
机构
[1] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy
关键词
nanoparticles; reprotoxicity; cryopreservation; ovarian cancer; ZINC-OXIDE NANOPARTICLES; TITANIUM-DIOXIDE NANOPARTICLES; OVARIAN-CANCER CELLS; SILVER NANOPARTICLES; GOLD NANOPARTICLES; TERM EXPOSURE; TOXICITY; OOCYTES; FOOD; NANOMATERIALS;
D O I
10.3390/ijerph192113748
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.
引用
收藏
页数:13
相关论文
共 119 条
[51]  
Karimipour M, 2018, INT J REPROD BIOMED, V16, P397
[52]   LAYSAN ALBATROSSES SWALLOW INDIGESTIBLE MATTER [J].
KENYON, KW ;
KRIDLER, E .
AUK, 1969, 86 (02) :339-&
[53]   Molecular effects of uptake of gold nanoparticles in HeLa cells [J].
Khan, Jameel Ahmad ;
Pillai, Beena ;
Das, Taposh Kumar ;
Singh, Yogendra ;
Maiti, Souvik .
CHEMBIOCHEM, 2007, 8 (11) :1237-1240
[54]   In vitro assessment of silver effect on porcine ovarian granulosa cells [J].
Kolesarova, Adriana ;
Capcarova, Marcela ;
Sirotkin, Alexander V. ;
Medvedova, Marina ;
Kovacik, Jaroslav .
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2011, 25 (03) :166-170
[55]  
Korsiak J, 2022, LANCET PLANET HEALTH, V6, pE400, DOI 10.1016/S2542-5196(22)00067-5
[56]   Silicosis: An Update and Guide for Clinicians [J].
Krefft, Silpa ;
Wolff, Jenna ;
Rose, Cecile .
CLINICS IN CHEST MEDICINE, 2020, 41 (04) :709-+
[57]   Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism [J].
Krol, A. ;
Pomastowski, P. ;
Rafinska, K. ;
Railean-Plugaru, V. ;
Buszewski, B. .
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2017, 249 :37-52
[58]   Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine [J].
Kuang, Huijuan ;
Zhang, Wanyi ;
Yang, Lin ;
Aguilar, Zoraida P. ;
Xu, Hengyi .
ENVIRONMENTAL TOXICOLOGY, 2021, 36 (04) :550-561
[59]   Metal-based nanoparticles, sensors, and their multifaceted application in food packaging [J].
Kumar, Antul ;
Choudhary, Anuj ;
Kaur, Harmanjot ;
Mehta, Sahil ;
Husen, Azamal .
JOURNAL OF NANOBIOTECHNOLOGY, 2021, 19 (01)
[60]   Nanotechnology and its challenges in the food sector: a review [J].
Kumar, P. ;
Mahajan, P. ;
Kaur, R. ;
Gautam, S. .
MATERIALS TODAY CHEMISTRY, 2020, 17