The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

被引:11
作者
Aloisi, Massimo [1 ]
Rossi, Gianna [1 ]
Colafarina, Sabrina [1 ]
Guido, Maurizio [1 ]
Cecconi, Sandra [1 ]
Poma, Anna M. G. [1 ]
机构
[1] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy
关键词
nanoparticles; reprotoxicity; cryopreservation; ovarian cancer; ZINC-OXIDE NANOPARTICLES; TITANIUM-DIOXIDE NANOPARTICLES; OVARIAN-CANCER CELLS; SILVER NANOPARTICLES; GOLD NANOPARTICLES; TERM EXPOSURE; TOXICITY; OOCYTES; FOOD; NANOMATERIALS;
D O I
10.3390/ijerph192113748
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.
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页数:13
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共 119 条
  • [1] Fe3O4 magnetic nanoparticles improve the vitrification of mouse immature oocytes and modulate the pluripotent genes expression in derived pronuclear-stage embryos
    Abbasi, Yasaman
    Hajiaghalou, Samira
    Baniasadi, Farzaneh
    Mahabadi, Vahid Pirhajati
    Ghalamboran, Mohammad Reza
    Fathi, Rouhollah
    [J]. CRYOBIOLOGY, 2021, 100 : 81 - 89
  • [2] Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles
    Agasti, Sarit S.
    Chompoosor, Apiwat
    You, Chang-Cheng
    Ghosh, Partha
    Kim, Chae Kyu
    Rotello, Vincent M.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (16) : 5728 - +
  • [3] Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?
    Aghamiri, Shahin
    Mehrjardi, Keyvan Fallah
    Shabani, Sasan
    Keshavarz-Fathi, Mahsa
    Kargar, Saeed
    Rezaei, Nima
    [J]. NANOMEDICINE, 2019, 14 (15) : 2083 - 2100
  • [4] Microplastics and Nanoplastics in Aquatic Environments: Aggregation, Deposition, and Enhanced Contaminant Transport
    Alimi, Olubukola S.
    Budarz, Jeffrey Farner
    Hernandez, Laura M.
    Tufenkji, Nathalie
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 52 (04) : 1704 - 1724
  • [5] Alves OL, 2014, NANOMED NANOTOXICOL, P1, DOI 10.1007/978-1-4614-8993-1_1
  • [6] [Anonymous], 2014, FDA2011D0489
  • [7] [Anonymous], REGULATION EC NO 122
  • [8] [Anonymous], 2020, SCCS161720 EUR COMM
  • [9] Interactions between oocytes and cumulus cells during in vitro maturation of porcine cumulus-oocyte complexes in a chemically defined medium: Effect of denuded oocytes on cumulus expansion and oocyte maturation
    Appeltant, R.
    Somfai, T.
    Nakai, M.
    Bodo, S.
    Maes, D.
    Kikuchi, K.
    Van Soom, A.
    [J]. THERIOGENOLOGY, 2015, 83 (04) : 567 - 576
  • [10] Applications of nanoparticles for diagnosis and therapy of cancer
    Baetke, S. C.
    Lammers, T.
    Kiessling, F.
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2015, 88 (1054)