Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: an in vitro study

被引：7

作者：

Song, Q. ^{[1
,2
]}

Risco, R. ^{[3
]}

Latina, M. ^{[1
,2
]}

Berthiaume, F. ^{[1
,2
]}

Nahmias, Y. ^{[1
,2
]}

Yarmush, M. L. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Engn Med, Boston, MA 02114 USA

[2] Shriners Burns Hosp, Boston, MA 02114 USA

[3] Univ Seville, Escuela Super Ingn, Seville 41092, Spain

来源：

OPTICS EXPRESS | 2008年 / 16卷 / 14期

关键词：

D O I：

10.1364/OE.16.010518

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm(2); (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells. (c) 2008 Optical Society of America.

引用

页码：10518 / 10528

页数：11

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