Ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for analysis of lignin-derived monomeric compounds in processed lignin samples

被引：41
|
作者：
Prothmann, Jens [1 ]
Sun, Mingzhe [1 ]
Spegel, Peter [1 ]
Sandahl, Margareta [1 ]
Turner, Charlotta [1 ]
机构：
[1] Lund Univ, Ctr Anal & Synth, Dept Chem, POB 124, SE-22100 Lund, Sweden
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2017年 / 409卷 / 30期
基金：
瑞典研究理事会;
关键词：
Column selectivity; Design of experiment; Ionisation efficiency; Lignin; Supercritical fluid chromatography; ELECTROSPRAY-IONIZATION; SWITCHGRASS LIGNIN; MOBILE-PHASE; COLUMNS; PHENOLS; DEPOLYMERIZATION; SEPARATION; ADDITIVES; OXIDATION;
D O I：
10.1007/s00216-017-0663-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The conversion of lignin to potentially high-value low molecular weight compounds often results in complex mixtures of monomeric and oligomeric compounds. In this study, a method for the quantitative and qualitative analysis of 40 lignin-derived compounds using ultra-high-performance supercritical fluid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) has been developed. Seven different columns were explored for maximum selectivity. Makeup solvent composition and ion source settings were optimised using a D-optimal design of experiment (DoE). Differently processed lignin samples were analysed and used for the method validation. The new UHPSFC/QTOF-MS method showed good separation of the 40 compounds within only 6-min retention time, and out of these, 36 showed high ionisation efficiency in negative electrospray ionisation mode.
引用
收藏
页码：7049 / 7061
页数：13
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