Biomarkers for Early Complications After Hematopoietic Stem Cell Transplantation

被引：12
作者：
Rowan, Courtney M. [1 ]
Paczesny, Sophie [2 ,3 ]
机构：
[1] Indiana Univ Sch Med, Dept Pediat, Div Crit Care, 705 Riley Hosp Dr,Room 4900, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Pediat, Melvin & Bren Simon Canc Ctr, 1044 West Walnut St,Room R4-425, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Dept Microbiol Immunol, Melvin & Bren Simon Canc Ctr, 1044 West Walnut St,Room R4-425, Indianapolis, IN 46202 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2019年 / 39卷 / 01期
关键词：
Biomarkers; Hematopoietic stem cell transplantation; Proteomics; Graft versus host disease; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; HEPATIC VENOOCCLUSIVE DISEASE; PLASMA BIOMARKERS; THROMBOTIC MICROANGIOPATHY; PREDICTIVE-VALUE; CLINICAL-TRIALS; RISK; ST2; MORTALITY;
D O I：
10.1016/j.cll.2018.10.005
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Advances in the field of omics have led to a significant expansion in biomarkers identified for complications after hematopoietic stem cell transplantation (HSCT). Biomarkers can offer an effective method for early identification of a specific disease and can be used to guide therapies. Ongoing investigations to discover biomarkers for acute graft-versus-host disease as well as other post-HSCT complications may improve early diagnosis, prognosis, and the development of new therapeutic targets. The authors review the most recent and validated diagnostic, prognostic, predictive, and response to treatment biomarkers for early complications following HSCT consistent with 2014 NIH consensus on biomarker criteria.
引用
收藏
页码：61 / +
页数：13
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