Electrosprayed chitosan/alginate/polyvinyl alcohol nanoparticles as boric acid carriers for 10Boron neutron capture therapy

被引：9
作者：
Wu, Wei-Cheng [1 ,2 ]
Wang, Shao-Hua [1 ]
Ou, Shu-Ting [1 ]
Liu, Yen-Wan Hsueh [3 ]
Liu, Bo-Heng [1 ]
Tseng, Fan-Gang [1 ,4 ]
机构：
[1] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Dept Engn & Syst Sci, Hsinchu 30013, Taiwan
[2] Acad Sinica, Taiwan Int Grad Program, Nano Sci & Technol Program, Taipei 115, Taiwan
[3] Natl Tsing Hua Univ, Inst Nucl Engn & Sci, Hsinchu 30013, Taiwan
[4] Acad Sinica, Res Ctr Appl Sci, Taipei 11529, Taiwan
来源：
NANOMEDICINE | 2020年 / 15卷 / 11期
关键词：
boron neutron capture therapy; cancer; electrospray; hydrogels; nanocarriers; polyvinyl alcohol; FE3O4; NANOPARTICLES; RECURRENT HEAD; BORON; CANCER; BNCT; TOXICITY; DELIVERY; 4-BORONO-2-F-18-FLUORO-L-PHENYLALANINE-FRUCTOSE; BIODISTRIBUTION; IMMOBILIZATION;
D O I：
10.2217/nnm-2019-0465
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To improve the killing efficacy of head and neck squamous cells (SAS) by boric acid-mediated boron neutron capture therapy (BNCT). Materials & methods: Boric acid-containing chitosan/alginate/polyvinyl alcohol nanoparticles (B-capNPs) were manufactured using the nano-electrospray process. Results: Less than 10% of the boric acid leaked from the B-capNPs over 2 days. The B-capNPs killed up to 2.8-fold more SAS cells and reduced cytotoxicity tenfold when compared with pure boric acid alone. B-capNPs show selective uptake in tumor cells with tumor/normal ratios of SAS to normal (NIH 3T3) and macrophage (RAW 264.7) cells of 4.0 and 3.5, respectively, which are greater than the minimum acceptable tumor/normal ratio for BNCT of 2.5. Conclusion: These findings illustrate that B-capNPs may be more superior as BNCT drugs than pure boric acid.
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收藏
页码：1067 / 1077
页数：11
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