Genetics of leukocyte telomere length and its role in atherosclerosis

被引：97
作者：
Aviv, Abraham [1 ]
机构：
[1] Univ Med & Dent New Jersey, Ctr Human Dev & Aging, New Jersey Med Sch, Newark, NJ 07103 USA
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2012年 / 730卷 / 1-2期
关键词：
Telomeres; Aging; Leukocytes; Genetics; Epigenetics; ENDOTHELIAL PROGENITOR CELLS; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; HEART-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PATERNAL AGE; LONGITUDINAL FINDINGS; SUSCEPTIBILITY LOCI; OXIDATIVE STRESS;
D O I：
10.1016/j.mrfmmm.2011.05.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Humans display a large inter-individual variation in leukocyte telomere length (LTL), which is influenced by heredity, sex, race/ethnicity, paternal age at conception and environmental exposures. LTL dynamics (birth LTL and its age-dependent attrition thereafter) mirror telomere dynamics in hematopoietic stem cells (HSCs). LTL at birth is evidently a major determinant of LTL throughout the human lifespan, such that individuals endowed with short (or long) LTL at birth probably have short (or long) LTL later in life. Therefore, the associations of short LTL with atherosclerosis and with diminished survival in the elderly may relate to short birth LTL, accelerated age-dependent LTL attrition, or both. The mechanisms underlying these associations are still not well understood, but they stem in part from genetic factors in control of telomere maintenance and the rate of HSC replication. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：68 / 74
页数：7
相关论文
共 134 条
  • [1] Racial differences in coronary artery calcification are not attributed to differences in lipoprotein particle sizes: The Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) Study
    Aiyer, Aryan N.
    Kip, Kevin E.
    Marroquin, Oscar C.
    Mulukutla, Suresh R.
    Edmundowicz, Daniel
    Reis, Steven E.
    [J]. AMERICAN HEART JOURNAL, 2007, 153 (02) : 328 - 334
  • [2] Telomere length in small-for-gestational-age babies
    Akkad, A
    Hastings, R
    Konje, JC
    Bell, SC
    Thurston, H
    Williams, B
    [J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2006, 113 (03) : 318 - 323
  • [3] Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    Alder, Jonathan K.
    Chen, Julian J. -L.
    Lancaster, Lisa
    Danoff, Sonye
    Su, Shu-Chih
    Cogan, Joy D.
    Vulto, Irma
    Xie, Mingyi
    Qi, Xiaodong
    Tuder, Rubin M.
    Phillips, John A., III
    Lansdorp, Peter M.
    Loyd, James E.
    Armanios, Mary Y.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) : 13051 - 13056
  • [4] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
    ALLSOPP, RC
    VAZIRI, H
    PATTERSON, C
    GOLDSTEIN, S
    YOUNGLAI, EV
    FUTCHER, AB
    GREIDER, CW
    HARLEY, CB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10114 - 10118
  • [5] Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita
    Alter, Blanche P.
    Baerlocher, Gabriela M.
    Savage, Sharon A.
    Chanock, Stephen J.
    Weksler, Babette B.
    Willner, Judith P.
    Peters, June A.
    Giri, Neelarn
    Lansdorp, Peter M.
    [J]. BLOOD, 2007, 110 (05) : 1439 - 1447
  • [6] Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Andrew, T
    Aviv, A
    Falchi, M
    Surdulescu, GL
    Gardner, JP
    Lu, XB
    Kimura, M
    Kato, BS
    Valdes, AM
    Spector, TD
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (03) : 480 - 486
  • [7] [Anonymous], DEATHS DEATH RAT LEA
  • [8] Leukocyte telomere length, breast cancer risk in the offspring: The relations with father's age at birth
    Arbeev, Konstantin G.
    Hunt, Steven C.
    Kimura, Masayuki
    Aviv, Abraham
    Yashin, Anatoliy I.
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2011, 132 (04) : 149 - 153
  • [9] Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
    Armanios, M
    Chen, JL
    Chang, YPC
    Brodsky, RA
    Hawkins, A
    Griffin, CA
    Eshleman, JR
    Cohen, AR
    Chakravarti, A
    Hamosh, A
    Greider, CW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (44) : 15960 - 15964
  • [10] Syndromes of Telomere Shortening
    Armanios, Mary
    [J]. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2009, 10 : 45 - 61
12345678910